尤瑞克林联合高压氧对急性脑梗死治疗的临床效果分析

Clinical Effect of Urocline Combined with Hyperbaric Oxygen in the Treatment of Acute Cerebral Infarction

目的探究将高压氧联合尤瑞克林应用于急性脑梗死患者治疗中的效果,评价其对患者精神状态、神经功能造成的影响,分析其治疗安全性。方法在我院数据库中调取时间段2017年9月至2018年10月收入的所有急性脑梗死患者的一般资料,根据本次实验要求选择其中42例患者作为实验对象,将所有患者进行随机两组均分后,分别命名为对照组与实验组,每组中录入21例患者。对照组患者应用尤瑞克林注射液进行治疗,实验组患者则在此治疗基础上加用高压氧进行治疗,对比两组患者治疗前后的神经功能缺损评分、WMS、MMSE、MOCA。评价两组患者治疗后的不良反应发生率,分析其用药效果。结果两组患者在治疗前NIHSS评分比较,其差异不明显,但在治疗完成后实验组患者的NIHSS评分明显优于对照组,差异显著。同时两组患者的WMS、MMSE、MOCA(P <0.05);实验组患者治疗后的不良反应发生率与对照组相比未见明显差异,不具有统计学意义。结论在对急性脑梗死患者进行治疗时,应用高压氧配合尤瑞克林进行联合用药,能够有助于改善患者的精神状态和神经功能,有助于减轻患者急性脑梗死状况,对于患者预后改善来说有积极意义,同时也不会引起患者发生其他用药不良反应,是一种安全且有效的治疗方案,值得推广使用。

Objective To explore the effect of hyperbaric oxygen(HBO) combined with uricline in the treatment of patients with acute cerebral infarction(ACI), to evaluate its impact on patients’ mental state and neurological function, and to analyze its treatment safety. Methods General data of all patients with acute cerebral infarction from September 2017 to October 2018 were collected in our hospital database. According to the requirements of this experiment, 42 patients were selected as experimental subjects. All patients were randomly divided into two groups, named as control group and experimental group, and 21 patients were included in each group. Patients in the control group were treated with Eureklin injection, while patients in the experimental group were treated with hyperbaric oxygen on the basis of this treatment. Neurological deficit scores, WMS, MMSE and MOCA were compared between the two groups before and after treatment. To evaluate the incidence of adverse reactions after treatment in two groups, and to analyze the effect of medication. Results There was no significant difference in NIHSS score between the two groups before treatment, but the NIHSS score of the experimental group was significantly better than that of the control group after treatment. At the same time, WMS, MMSE and MOCA of the two groups(P < 0.05);there was no significant difference in the incidence of adverse reactions after treatment between the experimental group and the control group. Conclusion When treating patients with acute cerebral infarction, the combination of hyperbaric oxygen and uricline can help to improve the mental state and neurological function of patients, alleviate the condition of patients with acute cerebral infarction, improve the prognosis of patients, and not cause other adverse drug reactions. It is safe and effective. The treatment scheme is worth popularizing.