小剂量糖皮质激素联合消炎痛用于亚急性甲状腺炎治疗效果的分析

Therapeutic Effect of Low dose Glucocorticoid Combined with Indomethacin on Subacute Thyroiditis

目的探讨在治疗亚急性甲状腺炎的过程中使用小剂量糖皮质激素联合消炎痛的效果分析。方法收集2017年5月至2018年12月在我院亚急性甲状腺炎的患者104例,随机分为参照组和研究组,研究组52例为小剂量糖皮质激素联合消炎痛治疗,参照组52例为小剂量糖皮质激素治疗,分析两组的治疗效果以及甲状腺疼痛消失时间、甲状腺肿大消失时间、体温恢复正常时间以及治疗前后血清中TSH、FT4、FT3水平的变化。结果研究组采用小剂量糖皮质激素联合消炎痛治疗,治疗总有效率96.15%(50/52)效果要优于参照组小剂量糖皮质激素治疗82.69%(43/52),并且治疗前两组的空FT3、FT4和TSH水平平均无差异,治疗后两组的空FT3、FT4和TSH水平均较治疗前有明显改善,并且治疗后研究组的FT3、FT4和TSH水平明显优于参照组,且结果显示有统计学差异(P <0.05)。结论小剂量糖皮质激素联合消炎痛的治疗效果明显,可临床应用推广。

Objective To investigate the effect of low dose glucocorticoid combined with indomethacin in the treatment of subacute thyroiditis. Methods 104 patients with subacute thyroiditis in our hospital from May 2017 to December 2018 were randomly divided into the reference group and the research group. 52 patients in the study group were treated with low dose glucocorticoid combined with indomethacin, and 52 patients in the control group were treated with low dose glucocorticoid. The changes of serum TSH, FT4 and FT3 levels before and after treatment. Results The total effective rate of low dose glucocorticoid combined with indomethacin in the study group was 96.15%(50/52) better than that in the control group 82.69%(43/52). There was no difference in the levels of FT3, FT4 and TSH between the two groups before treatment. After treatment, the levels of FT3, FT4 and TSH in the two groups were significantly improved compared with those before treatment, and after treatment, the levels of FT3, FT4 and TSH in the study group were significantly improved. The levels of TSH and TSH were significantly higher than those of the control group, and the results showed that there were significant differences(P<0.05). Conclusion Low dose glucocorticoid combined with indomethacin has obvious therapeutic effect and can be widely used in clinical practice.