不同梗死部位脑梗死患者血清炎性因子水平的变化及其临床意义

Dynamic changes and corresponding clinical significance of serum inflammatory factors in cerebral infarction patients with different infarction sites

目的研究不同梗死部位脑梗死患者血清炎性因子水平的动态变化及临床意义。方法选择洛阳东方医院2014年1月至2019年10月诊断的脑梗死患者60例为研究组,另选择同期健康体检者60例为对照组,比较两组受试者血清炎性因子如白细胞介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平。根据梗死部位将研究组患者分为脑干梗死组、大脑半球梗死组、小脑梗死组,每组20例,比较三组患者一般资料、不同时间段血清炎性因子水平变化及血清炎性因子与梗死部位的相关性。结果研究组IL-6、CRP、TNF-α水平均高于对照组(P<0.05);脑干梗死组入院第1、3天IL-6、CRP、TNF-α水平均高于大脑半球梗死组、小脑半球梗死组(P<0.05);大脑半球梗死组入院第1、3天IL-6、CRP、TNF-α水平均高于小脑半球梗死组(P<0.05)。结论不同梗死部位脑梗死患者血清炎性因子水平呈动态变化且表达存在差异,血清炎性因子可能对脑梗部位的判断具有一定价值。

ObjectiveTo investigate the dynamic changes of serum inflammatory factors in cerebral infarction patients with different infarction sites, and their clinical significance.MethodsSixty cerebral infarction patients treated in Luoyang Dongfang Hospital from January 2014 to October 2019 were selected as study group. And 60 healthy individuals who underwent physical examination in the same time period were selected as control group. The levels of serum inflammatory factors, including interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) were compared between the two groups. Patients in the study group were further divided into three subgroups according to the infraction sites, including brainstem infarction group, cerebral hemisphere infarction group and cerebellar infarction group, with 20 cases in each group. The general data and changes of serum inflammatory factor levels in different time periods were compared among three subgroups;then the correlation between serum inflammatory factors and infarction sites were analyzed.ResultsThe levels of IL-6, CRP and TNF-α in the study group were higher than those in the control group (P<0.05). Among three subgroups, the levels of IL-6, CRP and TNF-α at first and third day after hospitalization were the highest in the brainstem infarction group, followed by cerebral hemisphere infarction group and cerebellar infarction group (P<0.05).ConclusionsThe expression levels of serum inflammatory factors in cerebral infarction patients have dynamic changes, and they were different in patients with different infarction sites. Serum inflammatory factors may have certain value in the determination of cerebral infarction site.