康艾注射液联合同步放化疗治疗中晚期宫颈癌的效果观察

Effect Observation on Kang’ai Injection Combined with Concurrent Radiotherapy and Chemotherapy in Treatment of Advanced Aervical Aancer

目的探讨康艾注射液联合同步放化疗治疗中晚期宫颈癌的临床效果。方法选取2014年5月—2015年7月收治医院的中晚期宫颈癌患者100例,按照随机数字表法随机分成对照组和观察组,每组50例。对照组予以同步放化疗治疗,观察组在予以同步放化疗治疗基础上,联合予以康艾注射液静滴治疗。治疗后分别对两组的近期疗效、免疫功能、不良反应发生情况、生活质量以及远期生存率进行比较。结果①观察组的近期总治疗有效率为76.00%(38/50),显著高于对照组近期治疗有效率48.00%(24/50),差异有统计学意义(P<0.05);②对照组血清CD3^+、CD4^+、CD8^+水平较干预治疗前降低,CD4^+/CD8^+较治疗前升高(P<0.05);而观察组CD3^+、CD4^+、CD8^+水平较干预治疗前显著升高,CD4^+/CD8^+较治疗前降低(P<0.05);干预治疗后两组CD3^+、CD4^+、CD8^+及CD4^+/CD8^+水平比较差异均存在统计学意义(P<0.05);③观察组的恶心呕吐、腹痛腹泻的胃肠道不良反应程度明显小于对照组,差异有统计学意义(P<0.05);④观察组QOL评分、KPS评分显著优于对照组,差异均存在统计学意义(P<0.05);⑤观察组远期3a生存率均显著高于对照组,差异有统计学意义(P<0.05)。结论采用康艾注射液联合同步放化疗对中晚期宫颈癌患者进行治疗,能够有效提高近期疗效,减少化疗不良反应的发生,改善患者生活质量并提高患者远期生存率。

Objective To explore the effect of Kang’ai Injection combined with concurrent radiotherapy and chemotherapy in the treatment of advanced cervical cancer.Method A hundred cases of advanced cervical cancer in our hospital from May 2014 to July 2015 were randomly divided into control group and observation group,50 cases in each group.The patients in the control group were treated with concurrent radiotherapy and chemotherapy,while those in the observation group were treated with concurrent radiotherapy and chemotherapy combined with intravenous drip of Kang’ai Injection.Two months after intervention,the short-term efficacy,adverse reactions,quality of life and long-term survival rate of the two groups were compared.Results①The short-term total effective rate of the observation group was 76.00%(38/50),which was significantly higher than that of the control group(48.00%,24/50).②In the control group,the serum levels of CDCD3^+,CD4^+and CD8^+were reduced after treatment intervention.CD4^+/CD8^+was higher than that before treatment(P<0.05)and the observation group’s levels of CDCD3^+,CD4^+and CD8^+were significantly than those before treatment.CD4^+/CD8^+was decreased(P<0.05).After treatment,the two groups’levels of CDCD3^+,CD4^+,CD8^+and CD4^+/CD8^+were statistically significant(P<0.05).③The degree of gastrointestinal toxicity of nausea,vomiting,abdominal pain and diarrhea in the observation group was significantly lower than that in the control group.④The QOL score and KPS score of the observation group were better than those of the control group.⑤The long-term 3-year survival rate of the patients in the observation group was higher than that of the control group.Conclusion Kang’ai Injection combined with concurrent radiotherapy and chemotherapy can effectively improve the short-term efficacy of patients with advanced cervical cancer,reduce the occurrence of side effects of chemotherapy,improve the quality of life and the long-term survival rate of patients.