重症肺炎合并慢性心力衰竭患者应激状况指标及炎症指标检测的临床意义

Clinical significance of stress status and detection of inflammation indicators in severe pneumonia patients complicated with chronic heart failure

目的探讨重症肺炎患者合并慢性心力衰竭的应激状况及炎症指标的检测意义。方法随机抽取2018年1月至2019年1月河南科技大学第一附属医院收治的68例重症肺炎患者为研究对象,按照患者是否合并慢性心力衰竭分成观察组(n=38)和对照组(n=30),对两组患者的应激状况指标如丙二醛(MDA)、超氧化物歧化酶(SOD)和氧化低密度脂蛋白(Ox-LDL)进行检测。并对两组患者的炎症因子指标如降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)进行检测。结果观察组重症肺炎合并慢性心力衰竭患者MDA水平[(3.01±0.12)nmol/L]和Ox-LDL水平[(0.29±0.10)kU/L]低于对照组[(5.20±0.21)nmol/L,(0.60±0.11)KU/L],且SOD水平[(69.36±10.02)U/ml]高于对照组[(47.21±9.36)U/ml],差异有统计学意义(P<0.05)。观察组患者的血清炎症因子PCT水平[(0.59±0.30)mg/L]、CRP水平[(21.98±4.02)mg/L]、IL-6水平[(2.89±0.69)ng/L]和TNF-α水平[(33.21±4.88)ng/L]水平均高于对照组[(0.45±0.20)mg/L、(9.32±1.65)mg/L、(2.10±0.61)ng/L、(23.85±4.98)ng/L],差异均有统计学意义(P均<0.05)。结论当重症肺炎患者合并慢性心力衰竭时,其应激状况指标和血清中炎症因子水平有明显变化,通过检测重症肺炎患者的应激状况和炎症指标对判断患者是否合并心力衰竭具有重要意义。

Objective To investigate the clinical significance of stress status and detection of inflammation indicators in patients with severe pneumonia complicated with chronic heart failure.Methods Sixty-eight patients with severe pneumonia who were treated in the First Affiliated Hospital of Henan University of Science and Technology from January 2018 to January 2019 were randomly selected as the research subjects.They were divided into observation group(n=38)and control group(n=30)according to whether the patients complicated with chronic heart failure.Stress indicators of malondialdehyde(MDA),superoxide dismutase(SOD),and oxidized low-density lipoprotein(Ox-LDL)in the two groups by certain detection methods.And the inflammatory factor indicators procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α).Results The stress indicators such as the levels of MDA[(3.01±0.12)nmol/L]and ox LDL[(0.29±0.10)kU/L]in the observation group were lower than those in the control group[(5.20±0.21)nmol/L,(0.60±0.11)KU/L],and the level of SOD[(69.36±10.02)U/ml]was higher than that in the control group[(47.21±9.36)U/ml],the difference was statistically significant(P<0.05).The levels of serum inflammatory factors such PCT[(0.59±0.30)mg/L],CRP[(21.98±4.02)mg/L],IL-6[(2.89±0.69)ng/L]and TNF-α[(33.21±4.88)ng/L]in the observation group were higher than those in the control group[(0.45±0.20)mg/L,(9.32±1.65)mg/L,(2.10±0.61)ng/L,(23.85±4.98)ng/L],the differences were statistically significant(P<0.05).Conclusions When patients with severe pneumonia are complicated with chronic heart failure,their stress status and serum inflammatory factor indicators levels have significant changes.It is of great significance to detect whether patients complicated with severe pneumonia have heart failure by detecting the stress status and inflammation indicators.