利多卡因联合普瑞巴林对膝骨性关节炎疼痛患者的临床疗效

Effect of lidocaine combined with preabalin on patients with knee osteoarthritis pain

目的探讨利多卡因联合普瑞巴林对膝骨性关节炎疼痛患者的临床疗效。方法抽取2017年6月至2019年6月济宁市第二人民医院收治的膝骨性关节炎疼痛患者86例,依据随机数表法将其分为对照组和观察组,每组43例。对照组使用普瑞巴林治疗,在此基础上,观察组加用利多卡因注射液治疗。借助视觉模拟评分法(VAS)与膝关节WOMAC量表比较两组患者治疗前,治疗后1、4、8周的疼痛程度与关节炎严重程度,同时观察治疗前、治疗后2周血清炎性因子水平变化。结果治疗1、4、8周后,两组VAS评分均下降,且观察组的VAS评分低于对照组,差异有统计学意义(P<0.05);治疗后1、4、8周,两组WOMAC评分均下降,且观察组的WOMAC评分低于对照组,差异有统计学意义(P<0.05);治疗后,两组的各炎性因子水平均较治疗前降低,且观察组的白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平低于对照组,差异有统计学意义(P<0.05)。结论对膝骨性关节炎疼痛患者使用利多卡因联合普瑞巴林治疗,可有效缓解患者疼痛感,减轻关节炎严重程度,降低血清中炎性因子水平,治疗效果显著。

Objective To investigate the effect of lidocaine combined with pregabalin on patients with knee osteoarthritis pain.Methods Eighty-six patients with knee osteoarthritis pain admitted to the Second People’s Hospital of Jining from June 2017 to June 2019 were divided into control group and observation group according to the random number table,with 43 cases in each group.Control group was treated with pregabalin,and observation group was treated with lidocaine injection.Visual analogue scale(VAS)and the knee WOMAC scale were used to compare the pain level and severity of arthritis in the two groups pre-treatment and 1,4 and 8 weeks after treatment,and the changes in serum inflammatory factors pre-treatment and 2 weeks after treatment were observed.Results One,four and eight weeks after treatment,VAS scores in both groups decreased,and VAS scores in observation group were lower than those in control group,with statistically significant difference(P<0.05).One,four and eight weeks after treatment,WOMAC score in both groups decreased,and WOMAC score in observation group was lower than that in control group,with statistically significant difference(P<0.05).After treatment,the levels of inflammatory factors in both groups were lower than before treatment,and the levels of interleukin-1(IL-1),interleukin-6(IL-6),interleukin-8(IL-8)in observation group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusions Lidocaine combined with pregabalin can effectively relieve the pain of patients with knee osteoarthritis pain,reduce the severity of arthritis and serum inflammatory factors levels,and the treatment effect is significant.