动物分子影像技术在心肌梗死研究中的应用

Application of animal molecular imaging in myocardial infarction

心肌梗死(MI)是冠状动脉血流中断受阻而导致心肌缺血性坏死的疾病,临床症状主要表现为心肌疼痛、心力衰竭、心律失常、休克等。全球心肌梗死发病率逐年上升,且患者具有年轻化的趋势。虽然临床诊断和治疗方法也逐渐完善、效果显著,但由于疾病仍然具有普遍性和适应性,其疾病发生发展转归仍然是心血管疾病研究的热点。建立心肌梗死动物模型和运用分子影像学技术是不可或缺的手段。随着科学技术的发展,分子影像技术学更加前沿和多样化,形成了动物超声、动物MRI、动物SPECT/CT和动物PET/CT等多维度的分子影像方法,在诊断和辅助治疗心肌梗死疾病模型取得一系列阶段性的成果。本文综述了当前国内外分子影像技术在心肌梗死动物模型上的应用,展现了该技术的发展趋势和重要性,对临床诊断和治疗都具有重要的参考价值和借鉴意义。

Myocardial infarction(MI)is a disease that causes an interruption in coronary blood flow.Resultsing in ischemic myocardial necrosis.The clinical symptoms mainly include myocardial pain,heart failure,arrhythmia,and shock.The incidence of global myocardial infarction is increasing year by year,and patients are becoming younger.Clinical diagnosis and treatment method are largely improved,and the effect is remarkable.however,because of the universality and adaptability of the disease,its occurrence and development remain the focus of cardiovascular disease research.With the development of science and technology,molecular imaging has become more cutting-edge and diverse,and multiple technologies including animal ultrasound,CT,MRI,SPECT/CT,and PET/CT have achieved a series of outcomes in the diagnosis and treatment of myocardial infarction.This article summarizes the current application of molecular imaging technology to animal models of myocardial infarction,details its developmental trends and significance,and provides important references for clinical diagnosis and treatment.