精神病超高危人群脑低频振幅的研究

Study on brain amplitude of low-frequency fluctuation in patients at ultra high-risk for psychosis

目的:探索精神病超高危人群在静息状态下的脑功能变化。方法:纳入35例未进行干预或治疗的精神病超高危人群以及35名性别、年龄相匹配的健康对照者。对所有被试进行静息状态功能磁共振(fMRI)扫描以获取低频振幅(ALFF)值,采用精神病高危症状量表(SOPS)评估精神病超高危人群的临床症状,并分析超高危人群ALFF值与临床症状的关系。结果:与健康对照组相比,超高危人群组两侧颞上回、右侧顶下小叶ALFF增高,两侧小脑、左侧丘脑ALFF降低(TFCE矫正,P<0.01),且超高危人群组两侧小脑、左侧丘脑ALFF值与其一般症状呈负相关(TFCE矫正,P<0.05)。结论:精神病超高危人群存在广泛的脑功能异常,且这种脑功能异常与患者的临床症状有一定相关性。

Objective:To explore the changes of cerebral function in ultra high-risk(UHR)subjects for psychosis during resting state.Methods:A total of 35 UHR subjects and 35 healthy controls(HC)were scanned by restingstate functional magnetic resonance imaging(fMRI)to obtain the amplitude of low-frequency fluctuation(ALFF)value,scale of psychosis risk symptoms(SOPS)was used to evaluate clinical symptoms in UHR subjects,the correlations between ALFF and the severity of symptoms were examined using strict correlation analyses within brain areas.Results:Compared with the HC group,the UHR group showed a significant increase in ALFF values in bilateral superior temporal gyrus,right inferior parietal lobule and a significant decrease in ALFF values in bilateral cerebellum and left thalamus(TFCE corrected,P<0.01).The ALFF value of the bilateral cerebellum and left thalamus of the UHR group was negatively correlated with general symptoms(TFCE corrected,P<0.05).Conclusion:These findings suggest that there are extensive brain abnormalities in UHR subjects and abnormal activity brain regions may be associated with clinical symptoms.