树突状细胞在免疫耐受中的作用

The role of dendritic cells in immune tolerance

树突状细胞(dendritic cells,DCs)是一群异质性群体,它来源于髓样干细胞或由淋巴样干细胞分化而来,在免疫反应及免疫耐受中起重要作用。DCs可以通过阴性选择去除胸腺内自身反应T淋巴细胞和诱导产生调节T(regulatory T,Treg)细胞来促进中枢免疫耐受的形成,也可以通过多种机制促进外周免疫耐受的形成。目前研究发现,DCs在抗肿瘤免疫中扮演重要角色。然而肿瘤微环境中的抑制性细胞因子可以下调DCs的功能,从而诱导T细胞免疫耐受,现对DCs在中枢和外周免疫耐受中的作用,以及在肿瘤免疫中的作用进行概述。

Dendritic cells(DCs)are a heterogeneous population derived from myeloid or lymphoid stem cells,which play an important role in immune response and immune tolerance.DCs induce central immune tolerance through negative selection of autoreactive T cells and generation of regulatory T cells(Tregs)in the thymus.In addition,they also promote the acquisition of periphery immune tolerance through various mechanisms.Recent findings found that DCs play a vital role in the priming and maintenance of anti-tumor immunity.However,inhibitory cytokines in tumor microenvironment can down regulate the function of DCS and induce T-cell immune tolerance.In this review,we discuss the role of DCs in central and peripheral immune tolerance,as well as in tumor immunity.