正念认知疗法联合文拉法辛对抑郁症患者心理状态和生活质量的影响

Effect of mindfulness cognitive therapy combined venlafaxine on psychological state and quality of life in patients with depression

目的探讨正念认知疗法联合文拉法辛对抑郁症患者心理状态和生活质量的影响。方法将2018年02月~2019年02月本院接收的100例抑郁症患者随机分组,各50例。常规组予以文拉法辛治疗,研究组采用文拉法辛联合正念认知疗法治疗,比较两组临床疗效、生活质量、心理状态、下丘脑-垂体-肾上腺轴激素水平。结果研究组总体疗效高于常规组(P<0.05);研究组SF-36生活质量量表各维度评分高于常规组,HAMD抑郁评分低于常规组(P<0.05);研究组ACTH(促肾上腺皮质激素)、CRH(促肾上腺皮质激素释放激素)、CORT(皮质酮)、Cor(皮质醇)等激素水平均显著低于常规组(P<0.05)。结论采用文拉法辛联合正念认知疗法,不仅可以改善抑郁症患者下丘脑-垂体-肾上腺轴激素水平,而且还可以减轻患者负面情绪,提高患者生活质量,临床效果显著。

Objective To explore the effect of mindfulness cognitive therapy combined venlafaxine in patients with depression.Methods One hundred patients with depression in our hospital from February 2018 to February 2019 were selected and divided into two groups randomly.The regular group(n=50)was treated with venlafaxine,while the research group(n=50)was treated with venlafaxine combined with mindfulness cognitive therapy.The clinical efficacy,quality of life,mental state,and thalamic adrenal pituitary hormone levels were compared between the two groups.Results The overall efficacy of the study group was higher than that of the conventional group(P<0.05).The SF-36 quality of life scale of the study group was higher than that of the conventional group,and the HAMD depression score was lower than that of the conventional group(P<0.05).The levels of ACTH(adrenocorticotropic hormone),CRH(corticotropin releasing hormone),CORT(corticosterone),Cor(cortisol)in the study group were significantly lower than those in the conventional group(P<0.05).Conclusion The venlafaxine combined mindfulness cognitive therapy can not only improve the hormone level of the hypothalamicpituitary-adrenal axis,but also reduce the negative emotions,further improve the quality of life in depression patients.