血白介素-6、降钙素原及淋巴细胞亚群对脓毒症病情及其预后的评估价值

Evaluation Value of Serum Levels of Interleukin-6,Procalcitonin and Lymphocyte Subsets on the Severity and Prognosis of Sepsis

目的:探讨白介素-6(IL-6)、降钙素原(PCT)及淋巴细胞亚群对脓毒症患者的病情严重程度及其预后的评估作用。方法:以2018年1月-2020年2月广东省佛山市第一人民医院收治的脓毒症患者为研究对象,选择存活组和死亡组各50例,另选取同期进行体检的30例健康者作为对照组,比较其IL-6、PCT及淋巴细胞亚群水平。结果:存活组与死亡组治疗前、治疗后24 h的IL-6水平无明显差异(P>0.05),治疗后7 d、28 d的IL-6水平差异明显(P<0.05);死亡组与存活组治疗后24 h、7 d、28 d的PCT水平差异明显(P<0.05);死亡组与存活组在治疗前的淋巴细胞亚群各项指标均不存在差异(P>0.05);治疗后的淋巴细胞亚群各项指标差异显著(P<0.05);两组患者在淋巴细胞亚群各项指标上与对照组均有较大差异(P<0.05)。结论:动态检测IL-6、PCT及淋巴细胞亚群可作为脓毒症患者病情严重程度及其预后的评估指标之一。

Objective:To explore the evaluation value of interleukin-6(IL-6),procalcitonin(PCT)and lymphocyte subsets on the severity and prognosis of sepsis. Methods:The patients with sepsis selected from the First Peoples Hospital of Foshan from Jan 2018 to Feb 2020 according to the prognosis were divided into survival group(n=50)and death group(n=50). Healthy people who had physical examination at the same time were selected as the control group(n=30).IL-6,PCT and lymphocyte subsets were compared among the three groups. Results:There was no significant difference in levels of IL-6 between the death group and the survival group before treatment and 24 hours after treatment(P>0.05),and there were significant difference in levels of IL-6 at 7 and 28 days after treatment between the two groups(P<0.05).There were significant difference in levels of PCT at 24 hours,7 and 28 days after treatmentbetween the two groups(P<0.05). There were no significant difference in lymphocyte subsets between the death group and the survival group before treatment(P>0.05),while significantly different in lymphocyte subsets between the death group and the survival group after treatment 28 days(P<0.05). There were significant difference in lymphocyte subsets among the three groups,P<0.05. Conclusion:They may be one of the indicators of evaluation the severity and prognosis of sepsis by dynamic monitoring the levels of IL-6,PCT and lymphocyte subsets.