H型内皮细胞在成血管-成骨偶联中的作用

Effect of type H endothelial cells on the coupling of angiogenesis and osteogenesis

H型内皮细胞(CD31 hiEMCN hi)是一种特殊的血管内皮细胞亚型,主要分布于骨内膜及长骨干骺端。H型内皮细胞通过旁分泌等途径募集、激活骨祖细胞并促进软骨内成骨的进程,从而发挥促成骨功能;破骨细胞群与成骨细胞群等调节H型内皮细胞的生物活动。同时,H型内皮细胞的自我调控也与成血管、成骨过程密切相关。本文拟从H型内皮细胞的特性、细胞因子表达谱及其在成血管-成骨相互调节过程中的中介作用等方面作一综述,为建立基于成血管-成骨偶联的骨再生策略提供参考。

Type H endothelial cells(CD31hiEMCNhi),a special subtype of vascular endothelial cells,are distributed mainly in endosteum and long bone metaphysis.They recruit and activate osteoprogenitor cells and promote endochondral ossification through paracrine,thereby promoting osteogenesis.On the contrary,their biological activities can be regulated by osteoclasts and osteoblasts.At the same time,the mutual regulation of type H endothelial cells is also closely related to the process of angiogenesis and osteogenesis.This article reviews the characteristics and cytokine expression profiles and the mediating role in mutual regulation of angiogenesis and osteogenesis of the cells,offering an insight for establishment of a bone regeneration strategy based on the coupling of angiogenesis and osteogenesis.