心瓣膜置换术治疗大左心室心脏瓣膜病的临床疗效探讨

Investigation of the clinical effect of cardiac valve replacement on patients with valvular heart disease and giant left ventricle

目的探究大左心室心脏瓣膜病患者采用心瓣膜置换术治疗的临床疗效。方法选取30例采取心瓣膜置换术治疗的大左心室心脏瓣膜病患者作为观察组,同期30例采取心瓣膜置换术治疗的心脏瓣膜病患者作为对照组,同期30例采用药物保守治疗的大左心室心脏瓣膜病患者作为药物组。比较观察组患者治疗前后心功能指标左心室收缩末期内径[(LVESD)、左心室舒张末期内径(LVEDD)、左心房内径(LAD)]水平;观察组与对照组患者手术时间、重症加强护理病房(ICU)住院时间、气管插管时间;观察组与药物组的临床疗效。结果观察组患者经手术治疗后LVESD、LVEDD、LAD水平分别为(43.16±5.73)、(55.28±6.25)、(41.56±5.35)mm,均优于治疗前的(48.18±5.64)、(60.55±6.78)、(49.68±5.44)mm,差异均具有统计学意义(P<0.05)。观察组患者手术时间(4.89±0.64)h、ICU住院时间(5.45±0.82)d、气管插管时间(65.82±8.43)h均长于对照组的(4.10±0.43)h、(3.28±0.55)d、(43.56±5.35)h,差异具有统计学意义(P<0.05)。观察组治疗总有效率96.67%高于药物组的80.00%,差异具有统计学意义(P<0.05)。结论对大左心室心脏瓣膜病患者进行心瓣膜置换手术治疗,治疗效果较好。

Objective To investigate the clinical efficacy of cardiac valve replacement on patients with valvular heart disease and giant left ventricle.Methods There were 30 patients with valvular heart disease and giant left ventricle receiving cardiac valve replacement selected as the observation group,30 patients with valvular heart disease receiving cardiac vale replace ment during the same period as the control group,and another 30 patients with valvular heart disease and giant left ventricle receiving conservative medicine therapy during the same period as medication group.The observation group and the control group were treated by cardiac valve replacement,and the medication group was treated by simple drugs.The cardiac function indicators[left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),left atrial diameter(LAD)]before and after treatment in the observation group were compared.The operation time,hospitalization time at intensive care unit(ICU),intubation time of the observation group and control group were compared.The clinical efficacy between the observation group and medication group were compared.Results After treatment,the levels of LVESD,LVEDD,LAD of the observation group were(43.16±5.73),(55.28±6.25)and(41.56±5.35)mm respectively,which were all better than those before treatment(48.18±5.64),(60.55±6.78)and(49.68±5.44)mm,and the difference was statistically significant(P<0.05).The operation time(4.89±0.64)h,ICU hospitalization time(5.45±0.82)d and intubation time(65.82±8.43)h of the observation group were longer than those of the control group(4.10±0.43)h,(3.28±0.55)d and(43.56±5.35)h,and the difference was statistically significant(P<0.05).The total effective rate of treatment 96.67%of the observation group was higher than that of the medication group 80.00%,and the difference was statistically significant(P<0.05).Conclusion Cardiac valve replacement shows good therapeutic effect for patients with valvular heart disease and giant left ventricle.