静脉注射洛赛克与潘妥洛克治疗消化道出血合并痛风急性发作的临床效果比较

Comparison of clinical effect of intravenous injection of Losec or Pantoloc in the treatment of gastrointestinal hemorrhage with acute attack of gout

目的观察比较静脉注射奥美拉唑镁肠溶片(商品名:洛赛克)与泮托拉唑肠溶片(商品名:潘妥洛克)治疗消化道出血合并痛风急性发作的临床效果。方法100例消化道出血合并痛风急性发作患者,以随机数字表法分成实验组和对照组,每组50例。实验组患者采取静脉注射洛赛克+塞来昔布治疗。对照组患者采取静脉注射潘妥洛克+塞来昔布治疗,比较两组患者治疗前后视觉模拟评分法(VAS)评分、痛风累及关节数量、血尿酸水平、C-反应蛋白(CRP)水平以及止血时间与住院时间,消化道出血治疗效果。结果治疗后,两组患者VAS评分、痛风累及关节数量均降低,且实验组患者VAS评分(1.27±0.14)分、痛风累及关节数量(0.54±0.07)个均低于对照组的(1.83±0.12)分、(1.17±0.11)个,差异均具有统计学意义(P<0.05)。治疗后,两组患者血尿酸、CRP水平均低于治疗前,且实验组血尿酸水平(452.32±50.84)μmol/L、CRP水平(23.27±4.01)mg/L均低于对照组的(502.95±67.72)μmol/L、(34.54±5.11)mg/L,差异具有统计学意义(P<0.05)。实验组患者止血时间(23.33±2.72)h与住院时间(8.27±1.01)d均明显短于对照组的(28.76±3.16)h、(12.54±1.37)d,消化道出血治疗有效率96.00%高于对照组的84.00%,差异均具有统计学意义(P<0.05)。结论针对消化道出血合并痛风急性发作的患者以静脉注射洛赛克配合痛风常规治疗,可明显减轻痛风症状,降低血液指标水平,缩短止血时间与住院时间,提高消化道出血治疗疗效,效果理想。

Objective To observe and compare the clinical effect of intravenous injection of omeprazole magnesium enteric-coated tablets(trade name:Losec)or pantoprazole sodium enteric-coated tablets(trade name:Pantoloc)in the treatment of gastrointestinal hemorrhage with acute attack of gout.Methods A total of 100 patients with gastrointestinal hemorrhage with acute attack of gout were divided into experimental group and control group by random numerical table,with 50 cases in each group.Patients in the experimental group were treated by Losec and celecoxib,while patients in the control group were treated by Pantolok and celecoxib.The visual analogue scale(VAS)score,number of involved joints in gout,serum uric acid level,C-reactive protein(CRP)level,hemostasis time and hospitalization time,therapeutic effect of gastrointestinal hemorrhage were compared between the two groups.Results After treatment,VAS score,number of gout involved joints in the two groups decreased,and VAS score(1.27±0.14)points and the number of joints involved in gout(0.54±0.07)joints in the experimental group were lower than those in the control group(1.83±0.12)points and(1.17±0.11)joints,and the difference was statistically significant(P<0.05).After treatment,serum uric acid and CRP levels of the two groups were lower than those before treatment,and serum uric acid(452.32±50.84)μmol/L and CRP(23.27±4.01)mg/L of the experimental group were lower than those of the control group(502.95±67.72)μmol/L and(34.54±5.11)mg/L,and the difference was statistically significant(P<0.05).The hemostasis time(23.33±2.72)h,hospitalization time(8.27±1.01)d of the experimental group were obviously shorter than those of the control group(28.76±3.16)h,(12.54±1.37)d,and total effective rate of gastrointestinal hemorrhage 96.00%was higher than that of the control group 84.00%,and the difference was statistically significant(P<0.05).Conclusion For patients with gastrointestinal hemorrhage with acute attack of gout,intravenous Losec treatment combined with routine gout treatment can significantly reduce gout symptoms,reduce blood index levels,shorten hemostasis time and hospitalization time,and improve the therapeutic effect of gastrointestinal hemorrhage ideally.