基于痰瘀理论自拟方外用治疗膝骨关节炎患者42例临床观察

Clinical observation on 42 cases of knee osteoarthritis treated by external application of self-made prescription based on the phlegm stasis theory

目的观察从痰瘀理论立方的软伤洗剂治疗膝骨关节炎(KOA)临床疗效。方法42例膝骨关节炎患者,采用基于痰瘀理论立方的软伤洗剂外用熏熥治疗,比较患者治疗前后的WOMAC疼痛评分和视觉模拟评分法(VAS)评分。结果患者治疗前及治疗1、2、3、4周后WOMAC总评分分别为(289.333±16.141)、(77.619±6.484)、(60.381±5.896)、(46.143±5.450)、(34.619±4.208)分,比较差异具有统计学意义(P<0.05)。治疗后,患者WOMAC总评分呈现不断下降趋势,且第1周下降最为明显。患者治疗前及治疗1、2、3、4周后膝关节的疼痛程度、僵硬程度及活动困难程度评分比较差异具有统计学意义(P<0.05)。疼痛程度、僵硬程度及活动困难程度均在第1周改善最为明显,其中疼痛程度评分与活动困难程度评分呈现逐渐下降趋势,但是僵硬程度评分在第3周出现了反弹。研究过程中患者均无不良反应,未出现意外事件。结论基于痰瘀理论立方的软伤洗剂能够有效治疗膝骨关节炎,值得进一步研究及运用。

Objective To observe the clinical efficacy of knee osteoarthritis(KOA)treated by sSoft wound lotion based on the phlegm stasis theory.Methods A total of 42 patients with knee osteoarthritis were treated by fumigation of soft wound lotion based on the phlegm stasis theory,and WOMAC pain score and visual analogue scale(VAS)score before and after treatment were compared.Results Before treatment,1,2,3 and 4 weeks of treatment,WOMAC score were(289.333±16.141),(77.619±6.484),(60.381±5.896),(46.143±5.450)and(34.619±4.208)points respectively,and the difference was statistically significant(P<0.05).After treatment,the total score of WOMAC of patients showed a declining trend,and the decline was most obvious in the 1 st week.Before treatment,1,2,3 and 4 weeks of treatment,there was no statistically significant difference in score of pain,stiffness and difficulty in movement of knee joint(P<0.05).The degree of pain,stiffness,and difficulty in movement were most significantly improved in the 1 st week.Among them,the pain score and difficulty in movement score showed a gradual downward trend,but the stiffness score rebounded in the third week.During the study,there were no adverse reactions and no accidents occurred.Conclusion Soft wound lotion based on the phlegm stasis theory is effective in the treatment of knee osteoarthritis,and it is worthy of further research and application.