中山市第三人民医院2018年门诊第二类精神药品使用趋势分析

Analysis on the trend of classⅡpsychotropic drugs in outpatient clinics of Zhongshan Third People’s Hospital in 2018

目的探讨本院2018年门诊第二类精神药品使用情况,分析其合理性,为规范管理使用第二类精神药品提供参考依据。方法分析2018年1~12月2538张包含10种第二类精神药品处方,观察使用患者的年龄、时间分布、药物配伍等,对其限定日剂量(DDD)、用药频度(DDDs)、药物利用指数(DUI)等进行分析。结果2538张第二类精神药品处方中,男1375张,女1163张,男女比例1.18∶1.00。不同性别患者在不同年龄阶段第二类精神药品使用情况不同,35~50岁患者占比相对较高。2538张第二类精神药品处方,不同月份开出的处方数各有不同,2月最高,8月次之,7~10月连续四个月月均处方数均>200张,3~6月月均处方数较低,其中4月达到最低状态。10种第二类精神药品的DDD均在药物使用范围内,DDDs使用相对合理,10种药品中有8种药品的DUI≤1.0,仅有2种药品的DUI>1.0。2538张处方中有2种药品(奥沙西泮片、艾司唑仑片)的119张处方出现联合使用抗高血压药的情况,发生率为4.69%;有1种药物(酒石酸唑吡坦)的47张处方出现联合使用抗惊厥类药物(卡马西平)的情况,发生率为1.85%。结论10种第二类精神药品在中山市第三人民医院门诊的使用情况较为合理,但在药物配伍方面不够理想,尚需进一步改正和完善。

Objective To explore the use of classⅡpsychotropic drugs in the outpatient clinics of our hospital in 2018,and analyze its rationality,so as to provide a reference for standardized management and use of classⅡpsychotropic drugs.Methods From January to December 2018,2538 prescriptions containing 10 kinds of classⅡpsychotropic drugs were analyzed.The age,time distribution and drug compatibility of the patients were observed.The defined daily dose(DDD),defined daily dose system(DDDs),and drug utilization index(DUI)were analyzed.Results Among the 2538 prescriptions for classⅡpsychotropic drugs,1375 pieces were for males and 1163 pieces for females,with a male to female ratio of 1.18∶1.00.The use of classⅡpsychotropic drugs was different in different ages of patients of different genders,and the proportion of patients aged 35-50 was relatively high.2538 prescriptions for psychotropic drugs of the second category,the number of prescriptions issued in different months was different,the highest in February,followed by August,the average number of prescriptions for each of the four consecutive months from July to October was>200 pieces,the average number of prescriptions per month was low from March to June,and the lowest state was reached in April.The DDDs of 10 classⅡpsychotropic drugs were all within the scope of drug use,and the use of DDDs was relatively reasonable.Among the 10 drugs,8 drugs had a DUI≤1.0,and only 2 drugs had a DUI>1.0.Among the 2538 prescriptions,119 prescriptions of 2 drugs(oxazepam tablets and estazolam tablets)were combined with antihypertensive drugs,and the incidence was 4.69%;47 prescriptions of 1 drug(zolpidem tartrate)were combined with anticonvulsant drugs(carbamazepine),and the incidence was 1.85%.Conclusion The use of 10 kinds of classⅡpsychotropic drugs in the outpatient clinics of Zhongshan Third People’s Hospital is reasonable,but the drug compatibility is not ideal and needs further correction and improvement.