上海市境外输入性儿童新型冠状病毒感染38例病例系列报告

38 imported pediatric cases of SARS⁃CoV⁃2 infection from abroad in Shanghai:A case series report

目的了解上海市收治的境外输入性儿童新型冠状病毒(SARS-CoV-2)感染病例的流行病学和临床特征。方法收集2020年3月14日至2020年4月8日在上海市入境的38例经呼吸道标本核酸检测阳性确诊的SARS-CoV-2感染的儿童病例资料,分析其流行病学史、临床表现、实验室检查、胸部影像学以及治疗和转归情况。结果 38例患儿中,无症状感染16例(42.1%),非重症肺炎14例(36.8%),轻型8例(21.1%);37例(97.4%)来自欧洲和北美;26例(68.4%)无明确感染病例接触史或者聚集发病,12例(31.6%)有家庭内或学生宿舍内感染病例接触史。非肺炎组和肺炎组病例性别和年龄差异无统计学意义(P>0.05)。14例肺炎病例随访影像学均显示肺部病灶吸收治愈。16例无症状感染者在住院期间未出现症状和肺部影像学异常。7例有发热,热程平均2.5 d,11例有咳嗽,5例有咽痛,4例有鼻塞和流涕症状,6例使用过1~6 d羟氯喹治疗。38例均治愈出院,住院时间平均(18.5±3.4) d。结论境外输入性儿童SARS-CoV-2感染病例以无症状感染常见。有肺炎和无肺炎实验室检查结果无明显特异性。无症状感染者和非重症病例不推荐常规胸部影像学复查。

Objective To understand the epidemiological and clinical features of the 38 imported pediatric cases of SARS⁃CoV⁃2 infection in Shanghai.Methods The clinical data were collected from the 38 imported pediatric cases with laboratory⁃confirmed SARS⁃CoV⁃2 infection from March 14 to April 82020.The epidemiological history,clinical presentations,laboratory findings,chest radiological findings,treatment and outcomes were analyzed.Results Of the 38 imported cases,16(42.1%)were asymptomatic,14(36.8%)had non⁃severe pneumonia,and 8(21.1%)had mild illness.There were 37 cases(97.4%)from Europe and North America,26 cases(68.4%)without a definitive contact history,and 12 cases(31.6%)linked with family cluster infection or exposure to suspected cases in school dormitory.There was no statistical difference between the pneumonia group and the non⁃pneumonia group in terms of gender and age(P>0.05).The 14 pneumonia cases showed absorption of lung lesions by follow⁃up chest radiology,and the 16 asymptomatic cases did not develop any symptoms and radiological abnormalities during hospitalization.Seven cases had fever with a mean duration of 2.5 days,11 had mild cough,5 had sore throat,and 4 had runny nose.Hydroxychloroquine was used in the 6 cases for 1⁃6 days.All cases recovered uneventfully with a mean length of hospitalization of 18.5±3.4 days.Conclusion Asymptomatic infection was common among the imported pediatric cases of COVID⁃19 from abroad.There was no obvious difference of the laboratory findings between the pneumonia group and the non⁃pneumonia group.Routine re⁃detection of radiography is not recommended for asymptomatic and mild cases.