摘要
目的研究坤泰胶囊联合黄体酮胶囊治疗更年期综合征的临床疗效。方法选取2018年1月—2019年12月在洛阳市第五人民医院治疗的80例更年期综合征患者,所有患者随机分为对照组和治疗组,每组各40例。对照组患者口服黄体酮胶囊,4粒/次,2次/d。治疗组在对照组基础上口服坤泰胶囊,4粒/次,3次/d。两组患者接受治疗时间为3个月。观察两组的临床疗效,比较两组的Kupperma评分、更年期生活质量(MRS)评分、子宫内膜厚度、血清学指标、激素水平水平。结果治疗后,治疗组总有效率95.00%,显著高于对照组的77.50%(P<0.05)。治疗后,两组患者Kupperma评分和MRS评分显著降低(P<0.05),且治疗组降低程度较大(P<0.05)。治疗后,两组患者子宫内膜厚度显著升高(P<0.05),且治疗组升高较明显(P<0.05)。治疗后,两组患者血清内皮素(ET)和一氧化氮(NO)水平显著升高(P<0.05),且治疗组升高程度较大(P<0.05)。治疗后,两组患者黄体生成素(LH)、卵泡刺激素(FSH)水平明显降低,雌二醇(E2)水平明显升高(P<0.05);且治疗组改善较明显(P<0.05)。结论坤泰胶囊联合黄体酮胶囊治疗更年期综合征具有较好的临床疗效,能够改善患者临床症状,增加患者子宫内膜厚度,改善激素和血清学指标,安全性较高,值得在临床上推广应用。
Objective To study the efficacy of Kuntai Capsules combined with Progesterone Capsules in treatment of climacteric syndrome. Methods Patients(84 cases) with climacteric syndrome in Luoyang Fifth People’s Hospital from January 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Progesterone Capsules, 4 grains/time, twice daily. Patients in the treatment group were po administered with Kuntai Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and Kupperma score, MRS score, endometrial thickness, hormone level and serological index level. Results After treatment, the effective rate of the treatment group was 95.00%, which was significantly higher than 77.50% of the control group(P < 0.05). After treatment, Kupperma score and MRS score of the two groups were significantly reduced(P < 0.05), and the indicators of the treatment group was significantly lower than those of the control group(P < 0.05). After treatment, the levels of ET and NO in the two groups were significantly increased(P < 0.05), and the indicators of the treatment group was significantly higher than those of the control group(P < 0.05). After treatment, the levels of LH and FSH in the two groups were significantly reduced, but the levels of E2 in the two groups were significantly increased(P < 0.05), and the indicators of the treatment group was significantly better than those of the control group(P < 0.05). Conclusion Kuntai Capsules combined with Progesterone Capsules has clinical curative effect in treatment of climacteric syndrome, can improve the clinical symptoms, increase the thickness of endometrium, improve the hormone and serological indicators, with good safety, which is worthy of clinical application.
作者
爨米荣
杨晨光
吉冰
杜海燕
侯青霞
CUAN Mi-rong;YANG Chen-guang;JI Bing;DU Hai-yan;HOU Qing-xia(Department of Obstetrics and Gynecology,Luoyang Fifth People’s Hospital,Luoyang 471000,China;Xinxiang Medical University,Xinxiang 453003,China;Department of Laboratory,Luoyang Fifth People’s Hospital,Luoyang 471000,China;Color Doppler Ultrasound Room,Luoyang Fifth People’s Hospital,Luoyang 471000,China;Department of Gynecology,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000,China)
出处
《现代药物与临床》
CAS
2020年第6期1230-1234,共5页
Drugs & Clinic
关键词
坤泰胶囊
黄体酮胶囊
更年期综合征
临床症状评分
子宫内膜厚度
激素水平
血清学指标
Kuntai Capsules
Progesterone Capsules
climacteric syndrome
clinical symptom score
endometrial thickness
hormone level
serological index