妊娠期预防性补铁对孕妇促红细胞生成素及妊娠结局影响

The influence of preventive iron supplementation during pregnancy on erythropoietin level and pregnancy outcomes

目的:探讨妊娠期预防性补铁对孕妇促红细胞生成素等检验指标及妊娠结局的影响。方法:选取本院收治的100例孕11~12周孕妇,分别从妊娠12周开始预防性补充多糖铁复合物治疗(观察组)和不给予预防补铁治疗(对照组),比较临床疗效。结果:观察组补铁后孕28周、34周时铁缺乏(ID)及缺铁性贫血(IDA)发生率(26.0%、10.0%,44.0%、16.0%)均低于对照组(60.0%、36.0%,90.0%、44.0%),红细胞生成素、铁蛋白、血红蛋白、红细胞容积及相关免疫指标均较对照组改善明显,妊娠期并发症及妊娠结局(14.0%)均低于对照组(32.0%)(均P<0.05)。结论:妊娠期预防性补充铁对预防妇女缺铁性贫血疗效显著,同时可显著提高孕妇免疫功能并降低妊娠期并发症发生率,改善妊娠结局。

Objective:To investigate the influence of preventive iron supplementation during pregnancy for treating pregnant women on their erythropoietin level and pregnancy outcomes. Methods: 100 pregnant women in the 11-12 th gestational week were selected and were divided into study group and control group. The women in the study group were given preventive iron supplementation therapy from the 12 th gestational week and the women in the control group were not given iron supplementation therapy. The clinical efficacy was compared between the two groups. Results: The incidences of iron deficiency(ID) and iron deficiency anemia(IDA) of women in the 28 th and the 34 th gestational week in the study group were 26.0%, 10.0%, 44.0%, and 16.0%, respectively, which were significant lower than those(60.0%, 36.0%, 90.0%, 44.0%, respectively) of women in the control group. Compared with those of women in the control group, the levels of erythropoietin, ferritin, hemoglobin, red blood cell volume, and related immune indexes of women in the study group had improved significantly. The rate of pregnancy complications and adverse pregnancy outcomes of women in the study group was 14.0%, which were significant lower than that(32.0%) of women in the control group(all P<0.05).Conclusion: The preventive iron supplementation therapy during pregnancy can prevent IDA of pregnant women effectively, and can significantly improve their immune function and decrease the incidences of pregnancy complications and adverse pregnancy outcomes.