Sigma-1受体与卵巢储备功能低下不孕患者退行性变的关系

Correlation between Sigma-1 receptor and degenerative of infertile patients with low ovarian reserve

目的:研究分析Sigma-1受体与卵巢储备功能低下不孕患者退行性变的相关性。方法:选取2016年1月—2018年12月于本院生殖医学科收治的80例不孕女性,根据患者卵巢储备功能情况分组,功能低下47例为低下组,功能正常33例为正常组,比较并分析两组血浆、卵泡液及颗粒细胞中Sigma-1受体蛋白表达水平以及相关性。结果:低下组患者年龄,基础卵泡生成素(FSH)均高于正常组,抗苗勒氏管激素(AMH)、基础窦卵泡数(AFC)、获卵数以及可用胚胎数均低于正常组,颗粒细胞、血浆以及卵泡液中Sigma-1受体蛋白表达水平均低于正常组(均P<0.05)。患者血浆及卵泡液中中Sigma-1受体蛋白表达水平均与基础FSH、年龄呈负相关关系(P<0.05),与AMH、AFC、获卵数及可用胚胎数呈正相关关系(P<0.05)。结论:Sigma-1受体可能参与了卵巢储备功能调节过程,低表达水平与卵巢储备功能低下具有相关性,提示可作为临床潜在卵巢储备标志物。

Objective:To investigate the correlation between Sigma-1 receptor and degenerative of infertile patients with low ovarian reserve. Methods: 80 infertile women were enrolled in the study from January 2016 to December 2018. According to the ovarian reserve function, 47 patients with low ovarian reserve were included in observation group, and 33 patients with normal ovarian reserve were included in control group. The expression levels of Sigma-1 receptor protein in plasma, follicular fluid, and granular cell were compared between the two groups and the correlation of them were analyzed. Results: The levels of basal follicular generation hormone(FSH), age of patients in the observation group were significant higher than those of patients in the control group, but the levels of anti-Mulller’s hormone(AMH), basal antral follicular count(AFC), the acquired eggs, available embryos, and expression of plasma Sigma-1 receptor protein, follicular fluid, and granular cell of patients in the observation group were significant lower than those of patients in the control group(P<0.05). In the observation group, the expression of Sigma-1 receptor protein in granular cells and plasmaand follicular fluid was negative correlated with basal FSH level and age of patients, and was positive correlated with AMH level, AFC, number of eggs obtained, and number of available embryos(P<0.05). Conclusion: Sigma-1 receptor maybe participate in the regulation of ovarian reserve function, which’s low expression is associated with the low ovarian reserve, so it is suggests that Sigma-1 receptor may be used as a potential clinical marker for predicting ovarian reserve.