子痫前期孕妇脂质代谢水平与病情进展的相关性

Correlation analysis of lipid metabolism of pregnant women with preeclampsia and their disease progression

目的:探讨子痫前期孕妇脂质代谢水平及与病情进展的相关性。方法:收集2017年8月—2018年12月本院收治的子痫前期孕妇90例资料,其中轻度子痫前期50例(轻度组)、重度子痫前期40例(重度组),同期本院定期产前检查的正常孕妇30例(对照组),观察各组孕妇脂质代谢水平(TC、TG、LDL、HDL)、血清炎性相关因子(PON-1、Lp-PLA2、TNF-α、CRP、IL-6、APN)、维生素A、维生素E水平;记录新生儿结局;采用Spearman相关性分析脂代谢水平与子痫前期病情进展相关性。结果:TC、TG、LDL、LDL水平在对照组、轻度组、重度组依次升高, HDL水平依次下降(P<0.05);Lp-PLA2、TNF-α、CRP、IL-6水平在对照组、轻度组、重度组依次升高, PON-1、APN水平依次下降(P<0.05);维生素A、E水平在对照组、轻度组、重度组依次下降(P<0.05);孕妇胎盘重量、羊水污染、新生儿1min Apgar评分、体重等新生儿不良结局发生率在对照组、轻度组、重度组依次下降(P<0.05);TC、TG、LDL与子痫前期孕妇病情严重程度呈正相关性(r=0.581、0.934、0.541,P<0.05),HDL水平与子痫前期孕妇病情严重程度呈负相关性(r=-0.355,P<0.05)。结论:脂质代谢水平在子痫前期孕妇血清中表达异常,且脂质代谢指标与子痫前期密切相关,临床应重视妊娠期孕妇脂质代谢,做好子痫前期的防治工作。

Objective:To investigate the correlation between lipid metabolism of pregnant women with preeclampsia and their disease progression. Methods: The data of 90 pregnant women with preeclampsia were collected from August 2017 to December 2018, which included group A(50 women with mild preeclampsia) and group A(40 women with severe preeclampsia). Meanwhile, another 30 normal pregnant women were selected in group C. The levels of lipid metabolism(TC, TG, LDL, HDL), serum inflammatory related factors levels(PON-1, Lp-PLA2, TNF-α, CRP, IL-6, APN), and vitamin A and E levels of women in the three groups were observed. The neonatal outcomes of the three groups were recorded. And the correlation between lipid metabolism and the progression of preeclampsia was analyzed by Spearman correlation analysis. Results: The levels of serum TC, TG, LDL, Lp-PLA2, TNF-α, CRP, and IL-6 of women in group C, group A, and group B had increased in turn, but the levels of HDL, PON-1, and APN, and placental weight, amniotic fluid contamination rate, neonatal Apgar score at 1 min after born, and neonatal weight had decreased in turn(P<0.05). Conclusion: The level of lipid metabolism of pregnant women with preeclampsia is abnormal, and the lipid metabolism index is closely related to preeclampsia. The lipid metabolism of pregnant women should be paid more attention to in clinical practice for preventing preeclampsia.