急性脑梗死患者血管生成素样蛋白4表达及与颈动脉粥样硬化之间关系

Expression of Angiopoietin-like protein 4 and its relationship with carotid atherosclerosis in patients with acute cerebral infarction

目的探讨血管生成素样蛋白4(Angiopoietin-like protein 4,ANGPTL4)在急性脑梗死患者中的表达及与颈动脉粥样硬化之间的关系。方法选取急性脑梗死患者170例及对照组患者133例。根据颈动脉彩超结果,将脑梗死组分为无斑块组(26例)、稳定斑块组(40例)和不稳定斑块组(104例)3组,利用酶联免疫吸附法检测血清ANGPTL4水平。结果急性脑梗死患者血清ANGPTL4水平1052.75(586.53,1823.68)pg/ml明显高于对照组876.18(571.01,1528.93)pg/ml,差异有统计学意义(P=0.042);不稳定斑块组的血清ANGPTL4水平794.73(531.5,1580.06)pg/ml低于稳定斑块组1491.75(895.39,3960.34)pg/ml及无斑块组1223.34(851.66,3018.70)pg/ml(P<0.05);无斑块组与稳定斑块组的血清ANGPTL4水平差异无明显统计学意义(P=0.244);经Spearman相关性分析表明,血清ANGPTL4水平与高密度脂蛋白有关(r=0.194,P<0.05)。结论ANGPTL4与颈动脉硬化程度密切相关,可能为急性脑梗死及动脉硬化保护指标。

Objective To explore the expression of angiopoietin-like protein 4(ANGPTL4)in patients with acute cerebral infarction and the relationship between ANGPTL4 and carotid atherosclerosis.Methods 170 patients with acute cerebral infarction and 133 patients in the control group were selected.According to the results of carotid ultrasound,the cerebral infarction group was divided into three groups:non plaque group(26 cases),stable plaque group(40 cases)and unstable plaque group(104 cases).The serum level of ANGPTL4 was measured by enzyme-linked immunosorbent assay.Results The serum level of ANGPTL4 in patients with acute cerebral infarction was 1052.75(586.53,1823.68)pg/ml,which was significantly higher than 876.18(571.01,1528.93)pg/ml in the control group(P=0.042).The serum level of ANGPTL4 in the unstable plaque group was 794.73(531.5,1580.06)pg/ml,which was lower than 1491.75(895.39,3960.34)pg/ml in the stable plaque group and 1223.34(851.66,3018.70)pg/ml in the non Plaque group(P<0.05).There was no significant difference in the serum level of ANGPTL4 between plaque free group and stable plaque group(P=0.244).Spearman correlation analysis showed that the serum level of ANGPTL4 was related to HDL(r=0.194,P<0.05).Conclusion ANGPTL4 is closely related to the degree of carotid atherosclerosis,which may be a protective index of acute cerebral infarction and atherosclerosis.