摘要
目的:建立妇康宝口服液中阿胶成分的质谱鉴别方法。方法:样品经胰蛋白酶酶解后,通过超高效液相色谱-质谱法检测阿胶特征肽离子,进行阿胶成分的鉴别。结果:对5个厂家的61批样品进行测定,其中11批样品未检出阿胶成分,其余样品均检出有阿胶成分。结论:该鉴别方法专属性较强,可用于妇康宝口服液中阿胶成分的定性鉴别。
Objective:To establish a method for identification and quantitative evaluation of Asini Corii Colla in Fukangbao oral solution.Methods:After trypsin digestion,the characteristic peptide ions of Asini Corii Colla were detected by ultra-performance liquid chromatography-mass spectrometry.Results:61 samples from 5 manufacturers were tested.Among them,11 samples were not detected with the characteristic peptide ions of Asini Corii Colla.Conclusion:The identification method has strong specificity and can be used for qualitative identification of Asini Corii Collain component in Fukangbao oral solution.
作者
张玉婷
曲佳
周军
刘帅
鲁鑫
吴燕
Zhang Yuting;Qu Jia;Zhou Jun;Liu Shuai;Lu Xin;Wu Yan(Tianjin Institute of Drug Control,Tianjin 300070)
出处
《天津药学》
2020年第1期7-9,共3页
Tianjin Pharmacy
关键词
妇康宝口服液
阿胶鉴别
LC-MS
Fukangbao Oral Solution
identification of Asini Corii Colla
LC-MS