摘要
超声介导载药微泡靶向药物释放是一种新兴的靶向给药方法,以声学微泡包裹药物后,经静脉注入后在指定部位进行超声辐照,可实现缓释及靶向给药的双重作用。本文对超声微泡特性、超声微泡载药与给药机制、超声微泡介导靶向治疗的研究进展进行综述。
Ultrasound-targeted drug-loaded microbubbles destruction is a new targeted drug delivery method.After the microbubbles are loaded with drugs,they are injected intravenously and then irradiated by ultrasound at the designated site,which can achieve the dual effects of sustained-release and targeted drug delivery.In this paper,the progress of ultrasound microbubbles characteristics,drug delivery mechanism and ultrasound microbubble mediated targeted therapy are reviewed.
作者
周伊婕
郭键德
苏梦月
韩港男
宋西姊
Zhou Yijie;Guo Jiande;Su Mengyue;Han Gangnan;Song Xizi(Institute of Medical Engineering&Translational Medicine,Tianjin University,Tianjin 300072;College of Precision Instruments&Optoelectronics Engineering,Tianjin University,Tianjin300072)
出处
《天津药学》
2020年第1期56-60,共5页
Tianjin Pharmacy
基金
国家重点研发计划项目(No.2017YFB1300302)
国家自然科学基金重点项目(No.81630051)
国家自然科学基金青年科学基金项目(No.81801787)
中国博士后科学基金(No.2018M640238)
天津市自然科学基金(No.17JCQNJC10900)。
关键词
靶向治疗
超声
微泡
药物释放
targeted therapy
ultrasound
microbubble
drug delivery
