肝动脉化疗栓塞术治疗原发性肝癌的疗效观察

Efficacy of transcatheter arterial chemoembolization in the treatment of primary liver cancer

目的探讨肝动脉化疗栓塞术(TACE)治疗原发性肝癌的临床疗效及对免疫功能的影响。方法选取2016年2月至2019年3月间陕西省宝鸡市中心医院收治的80例原发性肝癌患者为观察组,另选取60例同期体检健康者为对照组。观察组患者采用TACE治疗,记录观察组患者治疗效果,比较两组受试者CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、血清甲胎蛋白(AFP)表达及不良反应。结果治疗后,观察组患者完全缓解11例,部分缓解38例,疾病稳定例25例,疾病进展6例,总缓解率为61.3%。治疗后,观察组患者CD3^+、CD4^+和CD4^+/CD8^+均高于治疗前,且观察组治疗前后均低于对照组,差异均有统计学意义(均P<0.05)。观察组患者治疗前后CD8^+及与对照组比较,差异均无统计学意义(P>0.05)。治疗后,观察组患者血清AFP低于治疗前,且观察组患者治疗前后均高于对照组,差异均有统计学意义(均P<0.05)。观察组患者治疗期间出现发热22例,胃肠道反应55例,疼痛34例,乏力23例,骨髓抑制12例。结论TACE治疗原发性肝癌疗效较好,可改善患者免疫功能,值得推广应用。

Objective To study the efficacy of transcatheter arterial chemoembolization(TACE)for primary liver cancer and the effect on immune function.Methods Eighty patients with primary liver cancer who admitted to Baoji Central Hospital from February 2016 to March 2019 were selected as the observation group,and another 60 healthy people who received physical examination at the hospital at the same time were selected as the control group.The observation group received TACE treatment.The treatment effect was recorded in the observation group,the expression of CD3^+,CD4^+,CD8^+and CD4^+/CD8^+and alpha fetoprotein(AFP)and adverse reactions were compared between the two groups.Results After the treatment,complete remission was achieved in 11 patients and partial remission was achieved in 38 patients in the observation group.Moreover,stable disease was achieved in 25 patients and progressive disease was achieved in 6 patients with the overall remission rate of 61.3%.After the treatment,levels of CD3^+,CD4^+and CD4^+/CD8^+increased in the observation group compared with before the treatment and the above levels were lower in the observation group than in the control group regardless the treatment(all P<0.05).There was no significant difference in the level of CD8^+between the two groups(P>0.05).Serum alpha-fetoprotein(AFP)was lower in the observation after the treatment than before the treatment with the observation group higher than the control group(all P<0.05).Fever occurred in 22 patients,gastrointestinal reaction 55 patients,pain 34 patients fatigue 23 patients and myelosuppression 12 patients in the observation group.Conclusion TACE is effective for primary liver cancer,which can improve immune function and is worthy of application and promotion.