基于D型氨基酸超分子水凝胶的制备和在癌症治疗方面的研究进展

Preparation of Supramolecular Hydrogel Made of D-Amino Acid and Their Applications in Cancer Treatment

寡肽自组装形成的超分子水凝胶,是一种在水溶液内被非共价键作用力驱动组装的三维纳米结构。它具有容易设计、易修饰的化学性质和良好的生物兼容性、较低的免疫毒性、特有的生物降解性、快速响应性等生物学特性。通过特别设计合成的L型氨基酸寡肽水凝胶因子在生物医学领域已经有广泛的应用,尤其是在癌症治疗方面的研究进展迅速。但L型氨基酸存在生物稳定性较差的缺陷,而D型氨基酸既具有L型氨基酸的多种优势,又比L型氨基酸在生物体内具有更好的生物稳定性。因此,利用D型氨基酸参与合成寡肽并自组装形成的超分子水凝胶在癌症治疗的研究会更广泛。主要介绍以D型氨基酸寡肽及其衍生物作为水凝胶因子制备超分子水凝胶的特点及其在癌症治疗方面的研究进展,并简单探讨了其在癌症治疗应用中面临的困难和挑战。

The supramolecular hydrogel,made of oligopeptide in a self-assembled way,is a kind of three-dimensional nanostructures formed through non-covalent bond force in aqueous solution. It owns so many advantages,such as easy to design and modify chemical properties, good biological modification, low immunotoxicity, easy to degrade, rapid response,and other biological characteristics. The L-amino acid oligopeptide hydrogelator,specially designed and synthesized, has been widely used in the field of biomedicine,especially in the research of cancer treatment. Due to better biological stability,D-amino acids are preferred in biomedicine than L-amino acids. Supramolecular hydrogel,selfassembled from oligopeptides synthesized from D-amino acids,will be more widely studied in cancer treatment. In this paper,supramolecular hydrogel prepared by D-amino acid oligopeptides and their derivatives as hydrogel are introduced,and their applications in the treatment of cancer are summarized. Also,the disadvantages and challenges of supramolecular hydrogel prepared by D-amino acid oligopeptides in cancer therapy are discussed.