乳腺癌首次足疗程化疗后血糖血脂代谢状况的临床分析

The metabolism of blood glucose and lipid in breast cancer patients after the first chemotherapy

目的:探讨乳腺癌患者首次接受足疗程化疗前、后血糖和血脂的代谢情况。方法:收集2016年12月至2020年1月于北京市朝阳区桓兴肿瘤医院就诊的首次接受化疗的乳腺癌患者,检测患者化疗前、后的血糖血脂水平,分析血糖和血脂水平的变化情况。结果:1356例女性乳腺癌患者,化疗前、后中位血糖水平分别为5.2和5.3 mmol/L,差异有统计学意义(P<0.05)。患者化疗前、后中位甘油三酯水平分别为1.2和1.6 mmol/L,差异有统计学意义(P<0.05)。患者化疗前、后中位小而密低密度脂蛋白水平分别为0.7和0.8 mmol/L,差异有统计学意义(P<0.05)。患者化疗前、后中位高密度脂蛋白水平分别为1.3和1.2 mmol/L,差异有统计学意义(P<0.05)。是否绝经和体质指数与患者的血糖、甘油三酯、低密度脂蛋白和小而密低密度脂蛋白水平均有关(均P<0.05)。结论:乳腺癌患者首次足疗程化疗后即可出现血糖血脂代谢异常。关注乳腺癌患者的心血管疾病,有助于综合改善患者的临床获益。

Objective To analyze the metabolism of blood glucose and lipid in breast cancer patients after the first chemotherapy.Methods Breast cancer patients who received chemotherapy for the first time from December 2016 to January 2020 were collected in our hospital,and their blood glucose and lipid levels were monitored.Patients were grouped according to different treatment plans.Non-parametric rank sum test was used for statistical analysis on SPSS software.Results There were 1356 female breast cancer patients were enrolled,blood glucose and lipid levels were compared before and after chemotherapy.Our results showed that baseline medium blood glucose was 5.2 mmol/L,lower than 5.3 mmol/L after chemotherapy(P<0.05).The baseline triglyceride(TG)was 1.2 mmol/L,lower than 1.6 mmol/L after chemotherapy(P<0.05).The baseline small dense low-density lipoprotein(sdLDL)was 0.7 mmol/L,lower than 0.8 mmol/L after chemotherapy(P<0.05).The baseline high density lipoprotein(HDL)was 1.3 mmol/L,higher than 1.2 mmol/L after chemotherapy(P<0.05).Patients′menstrual status and body mass index were related with blood glucose,TG,LDL and sdLDL(all P<0.05).Conclusions Abnormal metabolism of blood glucose and lipid are observed in breast cancer patients after the first chemotherapy.More awareness of cardiovascular disease in breast cancer patients might ensure their overall clinical benefits.