小而密低密度脂蛋白与心脑血管疾病的相关性

The correlation between small dense low-density lipoprotein and cardiovascular and cerebrovascular diseases

目的研究小而密低密度脂蛋白(sd-LDL)与心脑血管疾病的相关性并进行分析,旨在为心脑血管疾病的临床早期诊断、治疗提供思路。方法纳入2019年1月至8月心内科与脑外科收治的心脑血管疾病患者104例作为研究对象,其中脑出血11例,脑梗死75例,冠心病18例。另选取同期进行体检的健康人员50例作为正常对照组。分别比较各组人员的各项生化指标水平[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白型胆固醇(LDL-C)、高密度脂蛋白型胆固醇(HDL-C)、sd-LDL-C等],并作相关性分析。结果脑出血组sd-LDL-C水平高于正常对照组;脑梗死组TG、sd-LDL-C水平高于正常对照组,LDL-C低于正常对照组;冠心病组TG、sd-LDL-C水平高于正常对照组,差异均有统计学意义(P均<0.05)。Pearson线性相关分析显示,脑出血和冠心病患者sd-LDL-C分别与TG、LDL-C呈正相关关系(P均<0.05);脑梗死患者sd-LDL-C与TG呈正相关关系(P<0.05);Spearman秩相关分析示,sd-LDL-C水平与是否发生脑梗死呈正相关关系(r=0.491,P<0.01)。结论sd-LDL-C在脑出血、脑梗死、冠心病患者血清中均存在明显高水平,可能对上述疾病的早期诊断具有提示作用。

Objective To study the correlation between small dense low-density lipoprotein(sd-LDL)and cardiovascular and cerebrovascular diseases.The aim is to provide new ideas for early diagnosis and treatment of cardiovascular and cerebrovascular diseases.Methods A total of 104 patients with cardiovascular and cerebrovascular diseases admitted from the department of cardiology and brain surgery from January to August 2019 were selected as study objects,including 11 patients with cerebral hemorrhage,75 patients with cerebral infarction and 18 patients with coronary heart disease(CHD).In the same period,50 healthy individuals were served as the normal control group.Biochemical indexes of each group were compared(including TG,TC,LDL-C,HDL-C,sd-LDL-C),and correlation analysis was conducted.Results The sd-LDL-C levels in cerebral hemorrhage group were higher than that in normal control group;TG and sd-LDL-C levels in cerebral infarction group were higher than those in normal control group,and LDL-C was lower than that in normal control group;the TG,sd-LDL-C levels in CHD group were higher than those in normal control group(all P<0.05).Pearson linear correlation analysis showed that sd-LDL-C was positively correlated with TG and sd-LDL-C in patients with cerebral hemorrhage and CHD,respctively(all P<0.05);sd-LDL-C was positively correlated with TG in patients with cerebral infarction(P<0.05).Spearman rank correlation analysis showed that there was a positive correlation between sd-LDL-C and cerebral infarction(r=0.491,P<0.01).Conclusion There are significantly high levels sd-LDL-C in serum of patients with cerebral hemorrhage,cerebral infarction and CHD,which may play a role in the early diagnosis of the above diseases,and is worthy of clinical attention.