3.0T MRI PDFF和IP-OP对脂肪肝定量评估的价值

Values of 3.0T MRI PDFF and IP-OP in quantificative evaluation on fatty liver

目的:探讨3.0T磁共振成像(MRI)质子密度脂肪分数(PDFF)和同反相位(IP-OP)定量评估肝脏脂肪含量的应用价值,为脂肪肝无创性定量分析提供参考依据。方法:本组研究对象包括轻度脂肪肝患者34例、中重度脂肪肝患者29例和非脂肪肝患者(对照组)20例,均经肝穿刺活检确诊。采用MRI-PDFF和MRI-IP-OP技术检测各组患者肝脏脂肪分数(HFF),采用Kruskal-Wallis检验进行多组间比较,采用Mann-Whitney检验进行组间两两比较,同时进行Bonferroni校正。采用受试者工作特征(ROC)曲线分析2种技术定量评估脂肪肝的诊断效能。结果:各组患者MRI-PDFF和MRI-IP-OP的HFF比较差异有统计学意义(P<0.01)。中重度脂肪肝组患者MRI-PDFF的HFF较对照组和轻度脂肪肝组明显升高(P<0.01),轻度脂肪肝组患者MRI-PDFF的HFF较对照组明显升高(P<0.01)。中重度脂肪肝组患者MRI-IP-OP的HFF较对照组和轻度脂肪肝组患者明显升高(P<0.01),轻度脂肪肝组患者MRI-IP-OP的HFF较对照组明显升高(P<0.05)。ROC曲线显示,诊断轻度脂肪肝(对照组vs轻度脂肪肝组+中重度脂肪肝组),MRI-PDFF和MRI-IP-OP的HFF曲线下面积(AUC)分别为0.931和0.874;诊断中重度脂肪肝(对照组+轻度脂肪肝组vs中重度脂肪肝组),MRI-PDFF和MRI-IP-OP的HFF AUC分别为0.928和0.913。结论:对于轻度脂肪肝和中重度脂肪肝,MRI-PDFF具有更高的诊断效能,是一种精确而可靠的无创性肝脏脂肪变性定量分析方法。

Objective:To explore the application values of 3.0T magnetic resonance imaging(MRI)proton density fat-fraction(PDFF)and in-phase and opposed-phase(IP-OP)in the quantitative evaluation of liver fat content,and to provide the reference for non-invasive quantitative analysis of fatty liver.Methods:A total of 34 mild fatty liver patients,29 moderate to severe fatty liver patients and 20 non-fatty liver patients(control group)were selected.All patients were diagnosed by liver biopsy.The hepatic fat fractions(HFF)of patients were detected by MRI-PDFF and MRI-IP-OP techniques.Kruskal-Wallis test was used to compare the differences in HFF between various groups.Mann-Whitney test and Bonferroni correction were used to compare the differences of HFF between two groups.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnossis efficiency of each technique to evaluate the liver steatosis.Results:There were significant differences in HFF of MRI-PDFF and MRI-IP-OP of the patients between various groups(P<0.01).The HFF of MRI-PDFF of the patients in moderate and severe fatty liver group was higher than those in control group and mild fatty liver group(P<0.01),and the HFF of the patients in mild fatty liver group was higher than that in control group(P<0.01).The HFF of MRI-IP-OP the patients in moderate and severe fatty liver group was higher than those in control group and mild fatty liver group(P<0.01),and the HFF of the patients in mild fatty liver group was higher than that in control group(P<0.05).The ROC curve showed that the areas under curve(AUC)of MRI-PDFF and MRI-IP-OP in the diagnosis of mild fatty liver were 0.931 and 0.874,respectively,and the AUC of MRI-PDFF and MRI-IP-OP in the diagnosis of moderate and severe farry liver were 0.928 and 0.913,respectively.Conclusion:For the mild and moderate to severe fatty liver,MRI-PDFF has a more higher diagnosis efficiency,and it is a accurate,reliable,and non-invasive quantitative analysis method for liver steatosis.