对盐酸丙帕他莫所致不良反应的临床研究

Clinical study on adverse reactions induced by propacetamol hydrochloride

目的:探讨盐酸丙帕他莫所致的不良反应,以便为临床上合理使用该药提供参考。方法:将2017年1月至2019年6月期间在哈尔滨医科大学第一附属医院普外科和骨科接受手术治疗的452例患者作为研究对象。对这452例患者均进行手术治疗。术后,按照相应的规范使用盐酸丙帕他莫注射液对这452例患者进行镇痛治疗。在患者出院后,对其进行为期2个月的随访。然后,观察这452例患者不良反应的发生情况。结果:在用药后的第1天至第4天,在这452例患者中,有68例患者发生注射部位疼痛,有18例患者发生接触性皮炎,有10例患者发生低血压,有24例患者发生静脉炎,有12例患者发生头晕,其不良反应的发生率为29.2%。在用药后的第5天至第10天,在这452例患者中,有57例患者发生注射部位疼痛,有56例患者发生接触性皮炎,有9例患者发生低血压,有56例患者发生静脉炎,有9例患者发生头晕,其不良反应的发生率为41.4%。在用药后的第11天至第17天,在这452例患者中,有16例患者发生注射部位疼痛,有19例患者发生接触性皮炎,有4例患者发生低血压,有89例患者发生静脉炎,有2例患者发生头晕,其不良反应的发生率为28.8%。在用药后的第18天至第24天,在这452例患者中,有12例患者发生注射部位疼痛,有7例患者发生接触性皮炎,有2例患者发生低血压,有21例患者发生静脉炎,有1例患者发生头晕,其不良反应的发生率为9.5%。在用药后的第25天后,有6例患者发生注射部位疼痛,有5例患者发生接触性皮炎,有2例患者发生低血压,有5例患者发生静脉炎,其不良反应的发生率为3.9%。结论:盐酸丙帕他莫所致的不良反应主要发生在患者用药后的第5天至第10天,其发生不良反应的主要类型为注射部位疼痛、接触性皮炎、低血压、静脉炎、头晕等。

Objective:To investigate the adverse reactions caused by propacetamol hydrochloride,so as to provide reference for the rational use of the drug in clinical practice.Methods:A total of 452 patients who received surgical treatment in the general surgery department and orthopedics department of the First Affiliated Hospital of Harbin Medical University from January 2017 to June 2019 were studied.All 452 patients were treated surgically.After the operation,452 patients were treated with propacetamol hydrochloride injection according to the corresponding standard for analgesia.After discharge,the patients were followed up for 2 months.Then,the occurrence of adverse reactions in 452 patients was observed.Results:From day 1 to day 4 after administration,68 of the 452 patients had injection site pain,18 had contact dermatitis,10 had hypotension,24 had phlebitis,12 had dizziness,and the incidence of adverse reactions was 29.2%.From day 5 to day 10 after administration,57 of the 452 patients had injection site pain,56 had contact dermatitis,9 had hypotension,56 had phlebitis,9 had dizziness,and the incidence of adverse reactions was 41.4%.From the 11th to the 17th day after administration,16 of the 452 patients had injection site pain,19 had contact dermatitis,4 had hypotension,89 had phlebitis,2 had dizziness,and the incidence of adverse reactions was 28.8%.From day 18 to day 24 after administration,12 of the 452 patients had injection site pain,7 had contact dermatitis,2 had hypotension,21 had phlebitis,and 1 had dizziness.The incidence of adverse reactions was 9.5%.At 25 days after administration,6 patients had injection site pain,5 had contact dermatitis,2 had hypotension,and 5 had phlebitis,with an adverse reaction rate of 3.9%.Conclusion:The adverse reactions caused by propacetamol hydrochloride mainly occurred from the 5th day to the 10th day after the treatment,and the main types of adverse reactions were injection site pain,contact dermatitis,hypotension,phlebitis,dizziness,etc.