盐酸米诺环素软膏治疗瘘管型慢性根尖周炎的效果观察

Observation on the effect of Minocycline hydrochloride ointment in treati ng chronic periapical fistula

目的:探讨盐酸米诺环素软膏在对瘘管型慢性根尖周炎患者进行根管治疗中的应用效果。方法:选取2016年6月至2019年8月期间广东省中西医结合医院收治的167例瘘管型慢性根尖周炎患者作为研究对象。按照抽签的方式将这些患者分为对照组(n=83)和观察组(n=84)。两组患者入院后,均对其进行常规根管治疗。在此基础上,使用盐酸米诺环素软膏对观察组患者进行治疗。然后比较两组患者治疗的效果。结果:在治疗后的第1周及第2周时,观察组患者瘘管的闭合率均高于对照组患者,P<0.05。治疗后,观察组患者视觉模拟评分法(VAS)的评分低于对照组患者,P<0.05。治疗后,观察组患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)、白细胞介素1β(IL-1β)的水平均低于对照组患者,P<0.05。结论:用盐酸米诺环素软膏对瘘管型慢性根尖周炎患者进行根管治疗的效果较为理想,可有效地提高其瘘管的闭合率,减轻其患处的炎症反应,缓解其疼痛症状。

Objective:To investigate the effect of minocycline hydrochloride ointment in root canal therapy for chronic periapical fistula patients.Methods:167 patients with fistula-type chronic periapical periodontitis admitted to The Hospital of Integrated Traditional Chinese and Western Medicine of Guangdong Province from June 2016 to August 2019 were selected as the research objects.The patients were divided by lottery into a control group(n=83)and an observation group(n=84).After admission,both groups received routine root canal therapy.On this basis,minocycline hydrochloride ointment was used to treat the patients in the observation group.The two groups were then compared.Results:At the first and second weeks after treatment,the closure rate of fistula in the observation group was higher than that in the control group(P<0.05).After treatment,visual analogue scale(VAS)score in the observation group was lower than that in the control group(P<0.05).After treatment,the serum levels of tumor necrosis factor(TNF-),interleukin-6(IL-6),and interleukin-1(IL-1)in the observation group were all lower than those in the control group(P<0.05).Conclusion:Minocycline hydrochloride ointment can effectively improve the closure rate of fistula in patients with chronic periapical periodontitis,reduce the inflammation in the affected area,and relieve the pain symptom s.