对1例注射头孢哌酮钠/舒巴坦钠所致大疱性表皮松解坏死型药疹患者进行诊治的效果

Diagnosis and treatment of 1 case of bullae epidermolysis necrotic erupti on induced by cefoperazone sodium/Sulbactan sodium injection

目的:探讨对1例注射头孢哌酮钠/舒巴坦钠所致大疱性表皮松解坏死型药疹患者进行诊断和治疗的临床效果。方法:将2018年12月期间在云南省老年病医院就诊的1例注射头孢哌酮钠/舒巴坦钠所致大疱性表皮松解坏死型药疹患者作为研究对象。该患者因发生肺部感染使用注射用头孢哌酮钠/舒巴坦钠进行治疗。在用药期间,该患者出现大疱性表皮松解坏死型药疹,立即停止为其使用注射用头孢哌酮钠/舒巴坦钠,同时对其进行抗过敏治疗。然后,观察该患者的治疗效果。结果:治疗后,该患者的体温恢复正常,对其进行胸部CT检查的结果显示其肺部正常,其皮疹全部消失,康复出院。结论:临床医生在使用注射用头孢哌酮钠/舒巴坦钠对患者进行治疗前,需全面了解其是否存在使用该药的禁忌证,以减少其不良反应的发生。在使用注射用头孢哌酮钠/舒巴坦钠对患者进行治疗时,其若发生大疱性表皮松解坏死型药疹,需立即停药,并对其进行抗过敏治疗。

Objective:To investigate the diagnosis and treatment of 1 case of bullae epidermolysis necrotic eruption induced by injection of cefoperazone sodium/Sulbactam sodium.Methods:A patient with bullae epidermolysis necrotic type drug eruption caused by cefoperazone sodium/Sulbactan sodium injection was admitted to the Geriatric Hospital of Yunnan Province in December 2018 as the study object.The patient was treated with injectable cefoperazone sodium/sulbactam sodium for pulmonary infection.During the treatment period,the patient developed bullae epidermal release necrotic drug eruption and was immediately discontinued from cefoperazone/sulbactan for injection and given antiallergic treatment.Then,the treatment effect of the patient was observed.Results:After treatment,the patient’s body temperature returned to normal.Chest CT examination showed that his lungs were normal,his ski n rashes disappeared,and he recovered and left the hospital.Conclusion:Clinicians should fully understand the contraindications of cefoperazone/sulbactam before treating patients with cefoperazone/sulbactam for injection in order to reduce the incidence of adverse reactions.When cefoperazone sodium for injection/sulbactan sodium is used in the treatment of patients with bullous epidermal release necrosis drug eruption,the drug should be stopped immediately and antia llergic treatment should be given.