血液净化治疗脓毒症致急性肾损伤的临床研究

Clinical Study of Blood Purification in the Treatment of Acute Renal Injury Caused by Sepsis

目的研究血液净化治疗在脓毒症致急性肾损伤中的临床应用价值。方法回顾性分析2017年3月至2018年3月期间本院收治的脓毒症致急性肾损伤患者共50例的临床资料,用数字随机分方法将所有研究对象分成对照组和观察组,每组患者25例。对照组实施常规治疗,观察组实施血液净化治疗,对比两组患者治疗前后的血肌酐、血尿素氮水平及ICU住院时间。结果治疗前两组患者的血肌酐、血尿素氮指标对比差异无统计学意义(P>0.05)。治疗后观察组患者的血肌酐指标平均数据为(137.04±15.42)μmol/L,对照组患者的血肌酐指标平均数据为(244.53±19.87)μmol/L;治疗后观察组患者的血尿氮素指标平均数据为(13.14±2.94)mmol/L,对照组患者的血尿氮素指标平均数据为(17.72±3.47)mmol/L。两组数据相比差异明显,研究结果存在统计学意义(P<0.05)。结论血液净化的治疗方法在脓毒症致急性肾损伤患者中有良好的临床应用效果,值得进一步的推广使用。

Objective To study the clinical value of blood purification therapy in sepsis-induced acute renal injury.Methods The clinical data of 50 patients with sepsis-induced acute renal injury admitted to our hospital from March 2017 to March 2018 were retrospectively analyzed.All the research subjects were divided into control group and observation group by digital random method.25 patients in each group were treated with routine treatment in the control group and blood purification treatment in the observation group.The levels of serum creatinine,urea nitrogen and ICU hospitalization time before and after treatment were compared between the two groups.Results There was no significant difference in serum creatinine and urea nitrogen between the two groups before treatment(P>0.05).After treatment,the average data of serum creatinine index in the observation group was(137.04±15.42)μmol/L,while that in the control group was(244.53±19.87)μmol/L.After treatment,the average data of serum urea nitrogen index in the observation group was(13.14±2.94)mmol/L,and that in the control group was(17.72±3.47)mmol/L.There was significant difference between the two groups,and the results were statistically significant(P<0.05).Conclusion The treatment of blood purification has a good clinical application effect in sepsis-induced acute renal injury patients,and it is worth further promotion and use.