茶对氟化物和呕吐毒素对大鼠肝糖原分解的保护作用

The protective effect of tea on fluoride and deoxynivalenol on liver glycogen decomposition in rats

目的探究茶对氟与呕吐毒素染毒大鼠肝糖原含量降低的保护作用。方法将50只Wistar大鼠分为空白组、呕吐毒素染毒组、氟染毒组、联合染毒组和饮茶干预组,染毒5周后解剖大鼠,用蒽酮比色法试剂盒检测肝糖原含量。结果氟单独染毒、呕吐毒素与氟联合染毒后肝糖原含量显著性降低(P<0.05),呕吐毒素与氟联合染毒后的肝糖原含量显著性低于呕吐毒素单独染毒(P<0.05),饮茶干预后的肝糖原含量显著提高(P<0.05)。结论呕吐毒素和氟化物对肝糖原有损伤作用,茶对其损伤有保护性作用。

Objective To explore the protective effect of tea on the decrease of glycogen content in liver of rats exposed to fluoride and deoxynivalenol.Methods Fifty Wistar rats were divided into blank group,deoxynivalenol exposure group,fluoride exposure group,combined exposure group and tea drinking intervention group.After 5 weeks of exposure,the rats were dissected and the liver glycogen content was detected by anthrone colorimetry kit.Results The content of liver glycogen was significantly decreased after exposure to fluoride alone and combined exposure to deoxynivalenol and fluoride(P<0.05).The content of liver glycogen after combined exposure to deoxynivalenol and fluoride was significantly lower than that after exposure to deoxynivalenol alone(P<0.05),and the content of liver glycogen was significantly increased after drinking tea(P<0.05).Conclusion Deoxynivalenol and fluoride have the effect of reducing liver glycogen.Tea has protective effect on this damage.