DNA甲基化年龄研究进展

Research Progress of DNA Methylation Age

表观遗传学的进展使得借助年龄生物标志物预测个体年龄成为了可能。DNA甲基化是表观遗传学的重要组成部分,通过筛选年龄相关的甲基化位点构建表观遗传时钟,衍生出新的衰老生物标志物-DNA甲基化年龄(DNAm年龄)。DNAm年龄广泛应用于衰老、衰老相关疾病、法医学年龄推断等研究领域,但目前尚缺乏针对DNAm年龄的文献综述。本文就DNAm年龄的主要特点、经典的3大表观遗传时钟(Horvath时钟、Hannum时钟、DNA PhenoAge)以及DNAm年龄与死亡率、癌症及其他衰老相关疾病关联进行综述和探讨。

Advances in epigenetics have made it possible to predict an individual’s age using agerelated biomarkers. DNA methylation is an important part of epigenetics. DNA methylation age(DNAm age) is derived by building an epigenetic clock by screening age-related methylation CpG sites. DNAm age has been widely used in many research fields such as aging,age-related diseases,and age inference in forensic science,but there is still no literature review on DNAm age. In this paper,the main characteristics of DNAm age,the three classic epigenetic clocks(Horvath clock,Hannum clock,and DNA PhenoAge),and the associations of DNAm age with mortality, cancer and other age-related diseases are reviewed and summarized.