槟榔促进妇科腹部术后胃肠功能恢复的临床研究

The Clinical Study of Efficacy of Arecae Semen on Recovery of Gastrointestinal Function after Gynecological Surgery

目的观察槟榔对妇科腹部术后患者胃肠功能恢复的临床疗效及安全性,并探讨其可能的作用机制。方法采用前瞻性临床随机对照试验方法,纳入100例妇科腹部术后患者,随机分为槟榔组50例,对照组(安慰剂组)50例,观察患者术后首次排气时间、首次排便时间和胃肠功能评价指标,并测定血液中脑肠肽激素胃动素(MTL)。结果槟榔能够有效缩短妇科腹部术后患者的首次排气时间[(22.19±7.32)h]和首次排便时间[(46.00±15.85)h],与对照组比较差异均有统计学意义(P<0.05);槟榔组患者术后前3 d胃肠功能恢复疗效评分优于对照组(P<0.05)。槟榔组术后1、3 d MTL水平显著高于对照组(P<0.05)。结论槟榔能够促进妇科腹部术后胃肠功能恢复,其作用机理可能与调控脑肠肽激素MTL水平有关。

Objective To observe the clinical efficacy and safety of Arecae semen in the recovery of gastrointestinalfunction after gynecological abdominal surgery,and to explore its possible mechanism.Methods The principles andmethods of prospective clinical randomized controlled trials were used in 100 patients with gynecological abdominalsurgery,50 patients in Arecae semen group and 50 patients in control group.The recovery of gastrointestinalfunction after operation was evaluated with first exhaust time,first dejection time,and the accepted indexes ofgastrointestinal function,and blood brain-gut peptide motilin(MTL)of patients was also detected.Results Arecaesemen can effectively shorten the first exhaust time[(22.19±7.32)h]and the first dejection time[(46.00±15.85)h]after gynecological abdominal surgery,and there was statistical significance between the two groups after overallcomparison and covariance analysis(P<0.05).The overall effective score of the patients with Arecae semen groupwas better than that of the control group(P<0.05)on the third day after operation.The levels of MTL of patientsinArecae semen group on first and third days after operation were significantly higher than those of the patients incontrol group(P<0.05).Conclusion Arecae semen can promote the recovery of gastrointestinal function after gynecological abdominal surgery,and its mechanism may be related to the regulation of the level of brain-gutpeptide motilin(MTL).