午睡与高血压关系的Meta分析

Relationship between nap and hypertension in adults:An updated meta-analysis

目的:通过综合荟萃分析,调查午睡是否与患高血压风险增加有关。方法:文献检索、研究选择、资料提取等独立进行,效应大小估计用风险比(RR)和95%置信区间(CI)表示。结果:13篇文章中涉及119501名成年人的摘要数据纳入Meta分析。总体分析显示,在纳入的样本量中,未调整因素时,午睡与高血压风险有显著相关性(RR=1.11,95%CI:1.02~1.21,P=0.013),调整可能的混杂因素后,午睡与高血压风险仍然具有相关性(RR=1.07,95%CI:1.01~1.14,P=0.041)。在亚组分析中,有午睡习惯的女性(RR=1.13,95%CI:1.04~1.22,P=0.004)与高血压之间有明显的相关性,而在男性人群中未发现此种联系;≥45岁的人群(RR=1.16,95%CI:1.08~1.24,P<0.001)其午睡与高血压有显著的相关性。在剂量分析中发现午睡时长≥90 min的人群(RR=1.13,95%CI:1.01~1.27,P=0.04)与高血压之间有明显的相关性。结论:午睡是患高血压的风险因素,这种联系在女性人群中更为明显,差异有统计学意义;在≥60岁的老年人群中,午睡为高血压的保护因素。

Objective:To investigate whether nap is associated with an increased risk of hypertension through a comprehensive meta-analysis.Methods: Literature retrieval,research selection and data extraction were done independently and in duplicate.Effect-size estimates are expressed as risk ratio(RR)and 95%confidence interval(CI).Results: Summary data from 13 articles,involving a total of 119501 adults,were meta-analyzed.The overall analysis showed that in the included articles,when the factors were not adjusted,there was a significant association between nap and hypertension(RR=1.11,95%CI1.02 to 1.21,P=0.013).After adjusting the possible confounding factors,nap was still correlated with hypertension(RR=1.07,95%CI 1.01 to 1.14,P=0.041).In the subgroup analysis,there was a significant association between nap and hypertension in women(RR=1.13,95%CI 1.04 to 1.22,P=0.004),but this relationship was not recurred in men.And there was a significant association between nap and hypertension in people≥45 years old(RR=1.16,95%CI1.08 to 1.24,P<0.001).In the dose analysis,it was found that there was a significant association between high blood pressure and the population with nap duration≥90 min(RR=1.13,95%CI 1.01 to 1.27,P=0.04).Conclusion:Nap is a risk factor for hypertension,which is more obvious in women,and the difference is statistically significant.In the elderly people≥60 years,nap is a protective factor for hypertension.