参芎葡萄糖与前列地尔治疗慢性肾脏病的疗效比较

Comparison of Curative Effect between Shenqiong Glucose and Alprostadil in Treating Chronic Kidney Disease

目的观察参芎葡萄糖与前列地尔治疗慢性肾病的临床效果。方法选取2018年5月~2019年5月在我院诊治的94例慢性肾脏病患者为研究对象,采用随机数字表法分为对照组和观察组,各47例。对照组采用前列地尔治疗,观察组采用参芎葡萄糖治疗,比较两组临床治疗总有效率、治疗前后血清尿素氮、血红蛋白、肌酐、血尿酸、24 h尿蛋白及临床不良反应发生情况。结果观察组治疗总有效率为87.23%,与对照组的85.11%比较,差异无统计学意义(P>0.05);治疗后两组血清尿素氮、血红蛋白、肌酐、血尿酸、24 h尿蛋白均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论参芎葡萄糖与前列地尔均可有效治疗慢性肾脏病,但参芎葡萄糖在改善肾功能,尤其是血尿蛋白、肌酐、尿酸等指标方面优于前列地尔,且临床不良反应少,安全性良好。

Objective To observe the clinical effect of Shenqiong glucose and Alprostadil in treating chronic kidney disease.Methods A total of 94 patients with chronic kidney disease diagnosed and treated in our hospital from May 2018 to May 2019 were selected as the research object.They were divided into a control group and an observation group with a random number table method,each with 47 cases.The control group was treated with alprostadil,and the observation group was treated with Shenqiong glucose.The total clinical effectiveness of the two groups was compared.Serum urea nitrogen,hemoglobin,creatinine,blood uric acid,24 h urine protein and clinical adverse reactions before and after treatment were compared.Results The total effective rate of treatment in the observation group was 87.23%,compared with 85.11%in the control group,the difference was not statistically significant(P>0.05);after treatment,serum urea nitrogen,hemoglobin,creatinine,blood uric acid,and 24 h urine protein were low before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion Both Shenqiong glucose and Alprostadil can effectively treat chronic kidney disease,but Shenqiong glucose is superior to Alprostadil in improving renal function,especially blood urine protein,creatinine,uric acid and other indicators,and has fewer clinical adverse reactions and safety good.