血清CRP与ALB比值在宫颈癌中的变化及意义

Changes and Significance of the Ratio of Serum CRP to ALB in Cervical Cancer

目的探讨血清CRP与ALB比值在宫颈癌中的变化及意义。方法选取本院2016年12月~2019年12月接受治疗的95例宫颈病变患者作为研究对象,根据病理检查结果分为宫颈癌组(65例)和宫颈良性病变组(30例),另选取同期在我院体检的健康人群30名作为对照组,采集所有研究对象的外周静脉血,用电化学方法检测血清CA125,全自动生化仪检测血清CRP与ALB;比较3组CRP与ALB比值和CA125水平,同时比较宫颈癌组不同病理分型(宫颈鳞癌、宫颈腺癌、宫颈鳞腺癌、宫颈小细胞癌)及是否发生转移患者的CRP和ALB及CA125水平,分析宫颈癌患者CRP和ALB比值与CA125的相关性。结果宫颈癌组CRP与ALB比值及CA125高于宫颈良性病变组和对照组,差异有统计学意义(P<0.05);宫颈鳞癌患者CRP与ALB比值高于其他病理类型的宫颈癌患者,但差异无统计学意义(P>0.05);不同病理分型宫颈癌患者血清CA125水平比较,差异有统计学意义(P<0.05),且宫颈腺癌血清CA125水平高于宫颈鳞癌、宫颈鳞腺癌及宫颈小细胞癌患者;宫颈癌转移患者血清CRP与ALB比值和CA125水平高于未转移患者,差异有统计学意义(P<0.05);宫颈癌患者血清CRP与ALB比值和CA125呈正相关(r=0.522,P<0.05)。结论CRP与ALB比值在宫颈癌尤其是发生转移的患者中水平较高,可作为宫颈癌辅助诊断的敏感指标。

Objective To explore the changes and significance of the ratio of serum CRP to ALB in cervical cancer.Methods 95 patients with cervical lesions who were treated in our hospital from December 2016 to December 2019 were selected as the research object.According to the results of pathological examination,they were divided into cervical cancer group(65 cases)and cervical benign lesion group(30 cases).During the same period,30 healthy people who received physical examination in our hospital were used as a control group.The peripheral venous blood of all subjects was collected,serum CA125 was detected by electrochemical method,automatic biochemical analyzer to detect serum CRP and ALB;compare the CRP and ALB ratio and CA125 level of the three groups,and compare the different pathological types of cervical cancer group(cervical squamous cell carcinoma,cervical adenocarcinoma,cervical squamous cell carcinoma,cervical small cell carcinoma)and whether the CRP,ALB and CA125 levels of patients with metastasis have occurred,and the correlation between the ratio of CRP and ALB and CA125 in cervical cancer patients was analyzed.Results The ratio of CRP to ALB and CA125 in cervical cancer group were higher than those in benign cervical lesion group and control group,the difference was statistically significant(P<0.05);the ratio of CRP to ALB in patients with cervical squamous cell carcinoma was higher than that in patients with other pathological types of cervical cancer,but the difference was not statistically significant(P>0.05);compared with the serum CA125 levels of cervical cancer patients with different pathological types,the difference was statistically significant(P<0.05),and the serum CA125 level of cervical adenocarcinoma is higher than that of cervical squamous cell carcinoma,cervical squamous cell carcinoma and cervical small cell carcinoma;the ratio of serum CRP to ALB and CA125 level of cervical cancer metastatic patients are higher than those of non-metastatic patients,the difference was statistically significant(P<0.05);The ratio of serum CRP to ALB in patients with cervical cancer was positively correlated with CA125(r=0.522,P<0.05).Conclusion The ratio of CRP to ALB is higher in cervical cancer,especially in patients with metastasis,which can be used as a sensitive indicator for the auxiliary diagnosis of cervical cancer.