GDP方案对恶性淋巴瘤患者血清Hepc、IL-6和CEA水平的影响

Effects of GDP scheme on the serum levels of Hepc,IL-6 and CEA in patients with malignant lymphoma

目的探讨吉西他滨+顺铂+地塞米松(GDP)方案对恶性淋巴瘤患者血清铁调素(Hepc)、白介素6(IL-6)、癌胚抗原(CEA)水平的影响。方法选取2015年1月至2017年1月恶性淋巴瘤患者120例,依据随机数字表分为GDP组和CHOP组,每组60例。GDP组给予GDP方案化疗,CHOP组给予多柔比星+环磷酰胺+长春新碱+强的松(CHOP)方案化疗,比较2组血清Hepc、IL-6、CEA水平及治疗疗效、不良反应、生存情况。结果GDP组和CHOP组治疗后血清Hepc、IL-6、CEA水平明显低于治疗前,GDP组治疗后血清Hepc、IL-6、CEA水平明显低于CHOP组,差异有统计学意义(P<0.05);GDP组治疗有效率明显高于CHOP组,GDP组不良反应发生率明显低于CHOP组,差异有统计学意义(P<0.05);Kaplan-Meier生存曲线分析显示,GDP组2年生存率明显高于CHOP组,差异有统计学意义(P<0.05)。结论与CHOP比较,GDP方案可有效降低恶性淋巴瘤患者血清Hepc、IL-6、CEA水平,有利于提高患者的治疗疗效,且安全性好、生存预后好。

Objective To investigate the effects of gemcitabine+cisplatin+dexamethasone(GDP)scheme on the serum levels of hepcidin(Hepc),interleukin-6(IL-6)and carcinoembryonic antigen(CEA)in patients with malignant lymphoma.Methods A total of 120 patients with malignant lymphoma who were treated in our hospital from January 2015 to January 2017 were enrolled in the stdy,who were divided into GDP group and CHOP group ccording to the random number table,with 60 patients in each group.The patients in GDP group were treated by GDP scheme chemotherapy,however,the patients in CHOP group were treated by doxorubicin+cyclophosphamide+vincristine+prednisone(CHOP)scheme chemotherapy.The serum levels of Hepc,IL-6,CEA and therapeutic effects,adverse reactions,survival rate were observed and compared between the two groups.Results After treatment the serum levels of Hepc,IL-6,CEA in GDP group and CHOP GDP group were significantly lower than those before treatment,which in GDP group were significantly lower than those in CHOP group(P<0.05).The treatment effective rate in GDP group was significantly higher than that in CHOP group,and the incidence rate of adverse reaction in GDP group was significantly lower than that in CHOP group(P<0.05).The Kaplan-Meier survival curve analysis showed that,the 2-year survival rate in GDP group was significantly higher than that in CHOP group(P<0.05).Conclusion As compare with CHOP scheme,the GDP scheme can effectively decrease the serum levels of Hepc,IL-6 and CEA in patients with malignant lymphoma,which is helpful to improve the therapeutic effects,with better safety and survival prognosis.