血清凝集素样氧化型低密度脂蛋白受体-1表达水平与颈动脉斑块稳定性的相关性研究

Study on correlation between the expression levelof lectin-like oxidized low-density lipoproteinreceptor-1 in serum and stability of carotid plaque

目的探讨急性冠脉综合征(ACS)患者血清凝集素样氧化型低密度脂蛋白受体-1(LOX-1)水平与颈动脉斑块稳定性的相关性。方法选择78例ACS患者纳入观察组,根据颈动脉超声诊断结果将患者分为不稳定斑块组和稳定斑块组,以颈动脉无斑块健康者为对照组,检测3组人群血清LOX-1水平,并与超敏C反应蛋白(hs-CRP)结果相比较。结果不稳定斑块组和稳定斑块组的LOX-1水平显著高于对照组,且不稳定斑块组LOX-1水平显著高于稳定斑块组(P<0.05);血清LOX-1、hs-CRP水平与斑块稳定性呈负相关(r值分别为-0.673、-0.554,P<0.05)。结论血清LOX-1、hs-CRP水平与颈动脉斑块稳定性密切相关,可作为评价ACS斑块稳定性的血清学指标。

Objective To explore the correlation between lectin-like oxidized low-density lipoprotein receptor-1(LOX-1)in the serum of patients with acute coronary syndrome(ACS)and stability of carotid plaque.Methods A total of 78 patients with ACS were selected as observation group,and were divided into unstable plaque group and stable plaque group according to the results of carotid ultrasound,while the healthy people without plaque were included in control group.The levels of LOX-1 in three groups were detected and comparison between their levels and hypersensitive C reactive protein(hs-CRP)was performed.Results The levels of LOX-1 in the unstable plaque group and stable plaque group were significantly higher than that in the control group,and the level of LOX-1 in the unstable plaque group was significantly higher than that in the stable plaque group(P<0.05).The serum LOX-1 and hs-CRP were negatively correlated with the plaque stability(r=-0.673,-0.554,respectively,P<0.05).Conclusion The serum LOX-1 and hs-CRP levels are closely related to the stability of carotid plaque,which can be used as a serological index to evaluate the stability of ACS plaque.