血脂、血糖代谢水平及血压水平与糖尿病视网膜病变的相关性分析

Analysis on correlations between blood lipid,blood glucose metabolic levels as well as blood pressure and diabetic retinopathy

目的探讨血脂、血糖代谢水平及血压水平与糖尿病视网膜病变(DR)相关性。方法160例DR患者,按照盲和低视力分级标准分为盲组(n=30)、低视力组(n=50)和低视力以上组(n=80)。比较3组血脂、血糖代谢水平及血压水平,分析其与DR的相关性。结果盲组的收缩压(SBP)、空腹血糖(FPG)、糖化血红蛋白(HbAlc)、低密度脂蛋白胆固醇(LDL-C)、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇(LDL-C/HDL-C)显著高于低视力组(P<0.05),HDL-C水平显著低于低视力组(P<0.05)。盲组和低视力组的SBP、FPG、HbAlc、LDL-C、LDL-C/HDL-C显著高于低视力以上组(P<0.05),HDL-C水平显著低于低视力以上组(P<0.05)。相关性分析结果表明,SBP、FPG、HbAlc、LDL-C/HDL-C与DR的视力损害均呈正相关,均是其独立影响因素。结论监测SBP、FPG、HbAlC、LDL-C/HDL-C指标有利于预测DR,并为其及时治疗提供可靠参考。

Objective To investigate the correlations between blood lipid,blood glucose metabolic levels as well as blood pressure and diabetic retinopathy(DR).Methods A total of 160 DR patients were divided into blind group(n=30),low vision group(n=50)and low vision above group(n=80)according to bilindness and low vision criteria.The levels of blood lipid,glucose metabolism and blood pressure were compared among the three groups,and their correlations with DR were analyzed.Results Systolic blood pressure(SBP),fasting plasma glucose(FPG),glycosylated hemoglobin(HbAlc),low-density lipoprotein cholesterol(LDL-C),and ratio of LDL-C to high-density lipoprotein cholesterol(HDL-C)in the blind group were higher than those in the low vision group(P<0.05),and the level of HDL-C was lower than that in the low vision group(P<0.05).SBP,FPG,HbAlc,LDL-C,LDL-C/HDL-C in the blind group and the low vision group were higher than those in the low vision above group(P<0.05),and the HDL-C levels were lower than that in the low vision above group(P<0.05).The correlation analysis results showed that SBP,FPG,HbAlc,LDL-C/HDL-C were positively correlated with the visual impairment of DR,which were all independent influencing factors.Conclusion Monitoring SBP,FPG,HbAlc,LDL-C/HDL-C is helpful to predict the occurrence of DR and provide reliable reference for its timely treatment.