摘要
骨骼是人体代谢活跃组织,骨骼不断进行骨转换以维持结构的完整性和力学强度。骨骼所处微环境较为复杂,细胞外囊泡、microRNA、活性氧、激素及细胞因子等信号分子和微环境理化性质都参与调控骨骼细胞与细胞、细胞与系统间的交流,从多环节调控骨转换。本文综述骨微环境对骨转换的影响及其机制,为防治骨骼疾病提供新的思路。
Bone is an active tissue that is constantly remodeling to ensure bone integrity and strength.The microenvironment of bone is complicated,and signal molecules of bone microenvironment,including extracellular vesicles,microRNA,reactive oxygen species,hormones,cytokines,and physical-chemical properties of the microenvironment,play pivotal roles in regulating inter-cellular communication and bone turnover.We discuss the progress about the effects of bone microenvironment on bone turnover and its mechanism,which would provide new ideas for prevention and treatment of bone disorders.
作者
胡静
李梅
HU Jing;LI Mei(Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Key Laboratory of Endocrinology of National Health Commission of the People s Republic of China,Beijing 100730,China)
出处
《中华骨质疏松和骨矿盐疾病杂志》
CSCD
北大核心
2020年第3期255-260,共6页
Chinese Journal Of Osteoporosis And Bone Mineral Research
基金
国家自然科学基金面上项目(81873668)
北京市自然科学基金资助项目(7202153)
国家重点研发计划(2018YFA0800801)
中国医学科学院医学与健康科技创新工程项目(2016-I2M-3-003)。
关键词
骨微环境
骨转换
细胞外囊泡
MICRORNA
bone microenvironment/bone marrow niche
bone turnover
extracellular vesicles
microRNA
