肠离子通道在肠易激综合征发病机制中的作用研究进展

Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome

离子通道广泛存在于消化道黏膜中,其表达和(或)功能异常是肠易激综合征(IBS)重要的致病机制之一。电压门控钠离子通道(VGSCs)、电压门控钙离子通道(VGCCs)及瞬时受体电位通道(TRPs)等离子通道不同程度地参与IBS胃肠运动及内脏超敏,是调节胃肠运动和内脏超敏的关键病理生理机制及治疗靶点。

Ion channels are widely present in mucous membranes of the digestive tract,their abnormal expression and(or)function are important pathogenic mechanisms of irritable bowel syndrome(IBS).The plasma channels of voltage-gated sodium channels(VGSCs),voltage-gated calcium channels(VGCCs)and transient receptor potential channels(TRPs)are involved in IBS gastrointestinal motility and visceral hypersensitivity to varying degrees.They are key pathophysiological and therapeutic targets for regulating gastrointestinal motility and visceral hypersensitivity.