中晚期宫颈癌患者运用IMRT和VMAT治疗对预后的影响

Effects of IMRT and VMAT on the Prognosis of Patients with Advanced Cervical Cancer

目的:对比中晚期宫颈癌患者运用适形强调放疗(IMRT)和容积旋转调强放疗(VMAT)治疗对预后的影响。方法:选取2018年6月-2019年6月笔者所在医院收治的中晚期宫颈癌患者90例,按照随机原则分为观察组(VMAT治疗)和对照组(IMRT治疗),各45例。对比两组近期肿瘤控制率和早、晚期不良反应发生率。结果:观察组近期肿瘤控制率为95.56%,与对照组的93.33%比较差异无统计学意义(P>0.05);两组早期不良反应发生率比较,差异无统计学意义(P>0.05);观察组晚期放射性膀胱炎发生率为15.56%,放射性肠炎发生率为11.11%,均低于对照组,差异均有统计学意义(P<0.05)。结论:对中晚期宫颈癌患者运用IMRT和VMAT治疗的近期效果相当,且在早期不良反应方面无显著差异,但VMAT能够更好地保护危及器官,晚期不良反应较少,值得推广应用。

Objective:To compare the effects of intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) on the prognosis of patients with advanced cervical cancer.Method:From June 2018 to June 2019,90 patients with advanced cervical cancer admitted to the hospital were selected and randomly divided into the observation group (VMAT treatment) and the control group (IMRT treatment),45 cases in each group.Short-term tumor control rate and incidences of early and late adverse reactions were compared between the two groups.Result:The short-term tumor control rate in the observation group was 95.56%,compared with 93.33% of the control group,and the difference was not statistically significant (P>0.05).The incidence of early adverse reactions was compared between the two groups,and the difference was not statistically significant (P>0.05).In the observation group,the incidence of late radiation cystitis was 15.56%,and the incidence of radiation enteritis was 11.11%,which were lower than those of the control group,the differences were statistically significant (P<0.05).Conclusion:The short-term therapeutic effect of IMRT and VMAT in the treatment of advanced cervical cancer is the same,and there is no significant difference in the early adverse reactions.However,VMAT can better protect the organs at risk and has fewer late adverse reactions,so it is worth promoting its application.