左甲状腺素钠对妊娠合并桥本甲状腺炎患者的临床效果

Clinical Effect of Levothyroxine Sodium on Patients with Pregnancy with Hashimoto’s Thyroiditis

目的:探讨左甲状腺素钠(LT4)对妊娠合并桥本甲状腺炎(HT)患者的临床效果。方法:选择2018年7月-2019年1月笔者所在医院妊娠合并HT患者25例作为研究对象,均采用LT4治疗。比较治疗前及治疗4、8周后患者血清促甲状腺激素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)及抗甲状腺球蛋白抗体(TgAb)水平,并统计妊娠结局。结果:治疗8周后,TPOAb、TgAb、TSH水平均低于治疗4周和治疗前,FT4水平高于治疗4周和治疗前,差异均有统计学意义(P<0.05);25例患者均获得良好妊娠结局,无胎儿宫内生长受限、先天性甲减及畸形等情况。结论:LT4可显著改善妊娠合并HT患者甲状腺功能及妊娠结局,值得在临床中推广应用。

Objective:To explore the clinical effect of Levothyroxine Sodium (LT4) on patients with pregnancy with Hashimoto’s thyroiditis (HT).Method:A total of 25 cases with pregnancy with HT in our hospital from July 2018 to January 2019 were selected as the study subjects,all patients were treated with LT4.The levels of thyroid stimulating hormone (TSH),free thyroxine (FT4),thyroid peroxidase antibody (TPOAb) and anti-thyroglobulin antibody (TgAb) were compared before treatment and after 4 and 8 weeks of treatment,and the pregnancy outcomes were also calculated.Result:After 8 weeks of treatment,the levels of TPOAb,TgAb,and TSH were lower than 4 weeks of treatment and before treatment,and the level of FT4 was higher than 4 weeks of treatment and before treatment,and the differences were statistically significant (P<0.05).And 25 patients all achieved good pregnancy outcomes,there was no intrauterine growth restriction,congenital hypothyroidism and deformity.Conclusion:LT4 can significantly improve thyroid function and pregnancy outcomes in patients with pregnancy with HT,and it is worthy of popularization and application in clinic.