加味痛泻要方对肝郁脾虚型腹泻型肠易激综合征中医证候疗效及生活质量的影响

The Effect of Modified Tongxie Yaofang on TCM Syndrome and Quality of Life of Diarrhea-predominant Irritable Bowel Syndrome with Liver Depression and Spleen Deficiency

目的:探讨加味痛泻要方对肝郁脾虚型腹泻型肠易激综合征(IBS-D)中医证候疗效及生活质量的影响。方法:选择2017年11月-2019年4月在笔者所在医院就诊的64例肝郁脾虚型IBS-D患者为研究对象,采用随机数字表法将其分为观察组与对照组,各32例。对照组口服匹维溴铵片治疗,观察组采用加味痛泻要方治疗,疗程为1个月。比较两组中医证候疗效、生活质量、复发及不良反应情况。结果:治疗前,两组中医证候积分比较,差异无统计学意义(P>0.05);治疗后两组各项中医证候积分均有所降低,且观察组显著低于对照组,差异有统计学意义(P<0.05)。治疗前,两组生活质量评分比较,差异无统计学意义(P>0.05);治疗后两组生活质量评分均明显升高,且观察组显著高于对照组,差异有统计学意义(P<0.05)。观察组临床治疗总有效率为96.88%,高于对照组的78.13%,差异有统计学意义(P<0.05)。两组均未出现明显不良反应。观察组复发率为7.69%,明显低于对照组的50.0%,差异有统计学意义(P<0.05)。结论:应用加味痛泻要方治疗肝郁脾虚型IBS-D能够显著改善中医临床症状,减少疾病复发,安全性较好。

Objective:To discuss the effect of Modified Tongxie Yaofang on TCM syndrome and quality of life of diarrhea-predominant irritable bowel syndrome(IBS-D)with liver depression and spleen deficiency.Method:Sixty-four patients with IBS-D with liver depression and spleen deficiency admitted in our hospital from November 2017 to April 2019 were selected as the research objects.They were divided into the observation group and the control group by random number table method,with 32 cases in each group.The control group was treated with Pinaverium Bromide Tablets,and the observation group was treated with Modified Tongxie Yaofang,and the course of treatment was 1 month.The TCM syndromes curative effect,quality of life,recurrence and adverse reactions were compared between the two groups.Result:Before treatment,there was no significant difference in TCM syndrome scores between the two groups(P>0.05).After treatment,all TCM syndrome scores of the two groups were reduced,and the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in quality of life scores between the two groups(P>0.05).After treatment,the quality of life scores of both groups were significantly increased,and the observation group was significantly higher than the control group,the difference was statistically significant(P<0.05).The total effective rate of clinical treatment in the observation group was 96.88%,which was higher than 78.13%in the control group,the difference was statistically significant(P<0.05).There was no significant adverse reaction in both groups.The recurrence rate in the observation group was 7.69%,which was significantly lower than 50.0%in the control group,the difference was statistically significant(P<0.05).Conclusion:The application of Modified Tongxie Yaofang in the treatment of IBS-D with liver depression and spleen deficiency can significantly improve the clinical symptoms of TCM,reduce the recurrence of disease,and have a good safety.