脑梗死患者血尿酸水平与颈动脉中膜厚度相关性分析

Correlation Analysis of Uric Acid Level and Carotid Intima Media Thickness in Patients with Cerebral Infarction

目的:探讨脑梗死患者血尿酸水平(UA)与颈动脉中膜厚度(IMT)之间的相关性。方法:选取2016年8月-2019年9月笔者所在医院收治的脑梗死患者90例,根据IMT厚度分为颈动脉斑块组(A组)、颈动脉中膜增厚组(B组)及正常组(C组),每组30例。应用尿酸酶比色法检测患者血清UA水平,应用全自动生化分析仪对患者血清TC、TG、LDL-C进行检测,应用无创性高分辨彩色多普勒超声仪检测颈动脉,比较三组患者年龄、UA、TC、TG、LDL-C水平,并采用Pearson相关性分析观察UA和IMT之间的关系。结果:颈动脉斑块组患者的年龄、UA、TC、LDL-C均高于颈动脉中膜增厚组和正常组,差异有统计学意义(P<0.05)。尿酸水平与颈动脉中膜厚度呈正相关(r=0.418,P=0.000)。结论:脑梗死患者血尿酸水平与颈动脉中膜厚度呈显著相关性,随着患者血尿酸水平的升高,颈动脉中膜厚度增加。

Objective:To analysis correlation of uric acid level and carotid intima media thickness(IMT)in patients with cerebral infarction.Method:A total of 90 patients with cerebral infarction admitted to our hospital from August 2016 to September 2019 were divided into three groups according to IMT,carotid plaque group(group A),carotid middle membrane thickening group(group B)and normal group(group C).The UA level was measured by uricase colorimetry,TC,TG and LDL-C were measured by automatic biochemical analyzer.Carotid artery was detected by noninvasive high resolution color Doppler ultrasound.The age,UA,TC,TG and LDL-C levels of the three groups were compared,and the relationship between UA and IMT was analyzed by Pearson correlation.Result:The age,UA,TC and LDL-C of carotid plaque group were higher than those of carotid media thickening group and normal group,the differences were statistically significant(P<0.05).The level of UA was positively correlated with IMT(r=0.418,P=0.000).Conclusion:There is significant correlation between the level of serum UA and IMT in patients with cerebral infarction.The IMT increase with the increase of UA level.