利培酮联合阿立派唑治疗监狱老年精神分裂症的效果及对QTc间期的影响

Effect of Risperidone Combined with Aripiprazole for Treatment of Senile Schizophrenia and Its Effect on QTc Interval in Prison

目的:研究利培酮联合阿立哌唑治疗监狱中老年精神分裂症患者的效果及对QTc间期的影响。方法:抽取2015年4月-2018年6月于笔者所在医院住院的老年精神分裂症患者137例,随机分为对照组与联合组,对照组68例,联合组69例。对照组采用利培酮治疗,联合组采用利培酮联合阿立哌唑治疗。观察两组治疗3个月后临床疗效、治疗前及治疗1、2、3个月PANSS评分、治疗前及治疗3个月后QTc间期变化情况及不良反应发生率。结果:联合组总有效率为82.61%,明显高于对照组的61.76%,差异有统计学意义(P<0.05);联合组不良反应发生率为28.99%,明显低于对照组的55.88%,差异有统计学意义(P<0.05);两组治疗前PANSS评分比较,差异无统计学意义(t=0.976,P>0.05);联合组治疗1、2、3个月PANSS评分均低于对照组,差异均有统计学意义(t=6.987、7.463、11.817,P<0.05)。两组治疗前及治疗3个月后QTc间期比较,差异均无统计学意义(P>0.05)。结论:相较于利培酮单一治疗,利培酮与阿立派唑联合治疗监狱中老年精神分裂症患者的效果更好,且不良反应发生率低,对QTc间期影响不明显。

Objective:To investigate the efficacy of Risperidone combined with Aripiprazole for treatment of senile schizophrenia and its effect on QTc interval in prison.Method:A total of 137 patients with senile schizophrenia in our hospital from April 2015 to June 2018 were selected and randomly divided into the control group(68 cases)and the combination group(69 cases).The control group was treated with Risperidone,and the combination group was treated with Risperidone combined with Aripiprazole.The clinical efficacy after 3 months of treatment,PANSS scores before treatment and after 1,2 and 3 months of treatment,the changes of QTc interval before treatment and after 3 months of treatment,the incidence of adverse reactions of the two groups were observed.Result:The total effective rate in the combination group was 82.61%,which was higher than 61.76%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the combination group was 28.99%,which was lower than 55.88%of the control group,and the difference was statistically significant(P<0.05).Before treatment,the PANSS score was compared between the two groups,and the difference was not statistically significant(t=0.976,P>0.05).The PANSS scores of the combination group after 1,2 and 3 months of treatment were lower than those of the control group,and the differences were statistically significant(t=6.987,7.463,11.817,P<0.05).The QTc interval before treatment and after 3 months of treatment were compared between the two groups,and the differences were not statistically significant(P>0.05).Conclusion:Compared with Risperidone monotherapy,Risperidone combined with Aripiprazole has a better effect on patients with senile schizophrenia in prison,with low incidence of adverse reactions and no significant effect on QTc interval.