丙戊酸钠与氟哌啶醇治疗抽动症患儿的效果比较

Comparison of the Efficacy of Valproate and Haloperidol in the Treatment of Children with TIC Syndrome

目的:探讨丙戊酸钠与氟哌啶醇治疗抽动症患儿的效果。方法:选取2018年3月-2019年8月笔者所在医院收治的抽动症患儿72例,给予氟哌啶醇治疗的35例为B组,给予丙戊酸钠治疗的37例为A组。比较两组疗效、治疗前及治疗3个月后血清神经元特异性烯醇化酶(NES)水平、耶鲁综合抽动严重程度量表(YGTSS)评分、不良反应发生率。结果:A组治疗总有效率91.89%,高于B组的74.29%(P<0.05);治疗3个月后,A组血清NES水平、YGTSS评分低于B组(P<0.05);A组不良反应发生率5.41%,低于B组25.71%(P<0.05)。结论:与氟哌啶醇相比,丙戊酸钠治疗抽动症患儿效果显著,可改善神经功能,减轻病情,降低不良反应发生率。

Objective:To investigate the efficacy of Valproate and Haloperidol in the treatment of children with TIC syndrome.Method:A total of 72 children with TIC disease who admitted to our hospital from March 2018 to August 2019 were selected,35 patients receiving Haloperidol treatment were in group B,and 37 patients receiving Valproate treatment were in group A.The effect,serum neuron-specific enolase (NES) levels,YGTSS scores before and after 3 months of treatment,and the incidence of adverse reactions in the two groups were compared.Result:The total effective rate of group A was 91.89%,it was higher than 74.29% of group B (P<0.05).After 3 months of treatment,the serum NES level and YGTSS score of group A were lower than those of group B.The incidence of adverse reactions in group A was 5.41%,it was lower than 25.71% in group B (P<0.05).Conclusion:Compared with Haloperidol,Valproate is effective in the treatment of children with tourette syndrome,which can improve neurological function,alleviate the disease and reduce the incidence of adverse reactions.